Pattern formation and essential responses for regeneration in planarians

The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, patterning cues and a set of cellular and molecular responses collectively called the "missing tissue" or "regenerative" response. The missing tissue response has long been considered a fundamental requirement of planarian regeneration. follistatin, which encodes an extracellular Activin inhibitor, is required for the missing tissue response after head amputation, and for subsequent regeneration. We found that follistatin is required for the missing tissue response regardless of the wound context, but only causes regeneration failure after head amputation. This head regeneration failure involves follistatin-mediated regulation of Wnt signaling at wounds, and is not a consequence of a diminished missing tissue response.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Tewari, Aneesha G.(Aneesha Ghanhi)

Advisor dc:contributor.advisor

• Peter W. Reddien.

• Biology.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/122068

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/122068