The instructive roles of muscle cells in planarian regeneration

Regeneration requires both new cell production and patterning information to correctly place new tissue. Planarians are flatworms with remarkable capacity to regenerate after nearly any injury and to indefinitely maintain tissue homeostasis. Dividing cells, neoblasts, are the source of all new tissue, whereas positional information is hypothesized to be harbored by post-mitotic muscle, including the subepidermal body wall musculature. Single-muscle-cell mRNA sequencing along the anterior-posterior axis revealed regional gene expression within muscle cells. The resulting axial gene expression map included FGF receptor-like (FGFRL) homologs and genes encoding components of Wnt signaling. Two distinct FGFRL-Wnt circuits, involving juxtaposed anterior FGFRL and posterior Wnt expression domains, controlled head and trunk patterning.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Cote, Lauren E.(Lauren Esther)

Advisor dc:contributor.advisor

• Peter W. Reddien.

• Biology.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/122066

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/122066