Rheology of concentrated protein solutions and attractive colloidal dispersions

Therapeutic protein products with high solution concentration often possess extremely high viscosity and have difficulties in processing and delivery. It is desirable to predict and control the viscosity of protein solutions based on their interactions at the molecular level. Fundamental understanding on their rheology will greatly facilitate the development and engineering of biopharmaceuticals. In general, viscosity of attractive colloidal dispersions increases with their concentration and attraction strength, and diverges at the gel point. In this thesis, we investigate the mechanism of enhanced viscosity of concentrated protein solutions and colloidal dispersions due to inter-particle attractions. Coarse-grained models of protein solutions and colloidal dispersions are developed.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2018

Author dc:creator

• Wang, Gang,Ph. D.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• James W. Swan.

• Chemical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/121708

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/121708