{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/119709"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/119709","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"The application of deep learning to nucleus images for early cancer diagnostics","abstract":"Cancer remains a major concern for patients and early diagnosis can go a long way in treating patients. Current cancer diagnosis usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, early diagnosis remains a major challenge. Recent studies have shown that changes in fibroblast nuclei play a critical role in the early development of cancer. In addition, it is crucial that computational models are capable of justifying themselves when used in critical decisions such as diagnosing a patient with cancer. In this thesis, we use machine learning techniques on two dimensional nuclei images to show that computational models are capable of presenting human interpretable features as a means of justifying themselves. In addition, we use machine learning techniques on volumetric images of nuclei of cells in a co-culture model that represents the cancer tissue microenvironment to study changes the fibroblasts undergo. These studies pave the way for various approaches to early disease diagnosis.","abstract_html":"Cancer remains a major concern for patients and early diagnosis can go a long way in treating patients. Current cancer diagnosis usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, early diagnosis remains a major challenge. Recent studies have shown that changes in fibroblast nuclei play a critical role in the early development of cancer. In addition, it is crucial that computational models are capable of justifying themselves when used in critical decisions such as diagnosing a patient with cancer. In this thesis, we use machine learning techniques on two dimensional nuclei images to show that computational models are capable of presenting human interpretable features as a means of justifying themselves. In addition, we use machine learning techniques on volumetric images of nuclei of cells in a co-culture model that represents the cancer tissue microenvironment to study changes the fibroblasts undergo. These studies pave the way for various approaches to early disease diagnosis.","abstract_has_math":false,"creators":["Soylemezoglu, Ali Can"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.","school":null,"contributors":[],"advisors":["Caroline Uhler."],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-22T22:22:17Z","subjects":["Electrical Engineering and Computer Science."],"languages":["eng"],"rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/119709","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Caroline Uhler."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."]},{"key":"dc:creator","label":"Author","values":["Soylemezoglu, Ali Can"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-12-18T19:46:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-12-18T19:46:43Z"]},{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Electrical Engineering and Computer Science."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/119709"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.","This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.","Cataloged from student-submitted PDF version of thesis.","Includes bibliographical references (pages 69-72)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Cancer remains a major concern for patients and early diagnosis can go a long way in treating patients. Current cancer diagnosis usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, early diagnosis remains a major challenge. Recent studies have shown that changes in fibroblast nuclei play a critical role in the early development of cancer. In addition, it is crucial that computational models are capable of justifying themselves when used in critical decisions such as diagnosing a patient with cancer. In this thesis, we use machine learning techniques on two dimensional nuclei images to show that computational models are capable of presenting human interpretable features as a means of justifying themselves. In addition, we use machine learning techniques on volumetric images of nuclei of cells in a co-culture model that represents the cancer tissue microenvironment to study changes the fibroblasts undergo. These studies pave the way for various approaches to early disease diagnosis."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M. Eng."]},{"key":"dc:title","label":"Title","values":["The application of deep learning to nucleus images for early cancer diagnostics"]}]}],"canonical_facts":{"dc:contributor.advisor":["Caroline Uhler."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."],"dc:creator":["Soylemezoglu, Ali Can"],"dc:date.accessioned":["2018-12-18T19:46:43Z"],"dc:date.available":["2018-12-18T19:46:43Z"],"dc:date.issued":["2018"],"dc:description":["Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.","This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.","Cataloged from student-submitted PDF version of thesis.","Includes bibliographical references (pages 69-72)."],"dc:description.abstract":["Cancer remains a major concern for patients and early diagnosis can go a long way in treating patients. Current cancer diagnosis usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, early diagnosis remains a major challenge. Recent studies have shown that changes in fibroblast nuclei play a critical role in the early development of cancer. In addition, it is crucial that computational models are capable of justifying themselves when used in critical decisions such as diagnosing a patient with cancer. In this thesis, we use machine learning techniques on two dimensional nuclei images to show that computational models are capable of presenting human interpretable features as a means of justifying themselves. In addition, we use machine learning techniques on volumetric images of nuclei of cells in a co-culture model that represents the cancer tissue microenvironment to study changes the fibroblasts undergo. These studies pave the way for various approaches to early disease diagnosis."],"dc:description.degree":["M. Eng."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/119709"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Electrical Engineering and Computer Science."],"dc:title":["The application of deep learning to nucleus images for early cancer diagnostics"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:22:17Z"}