{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/119068"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/119068","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes","abstract":"Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.","abstract_html":"Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.","abstract_has_math":false,"creators":["Sun, Jessica H"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Materials Science and Engineering.","school":null,"contributors":[],"advisors":["Michael S. Strano."],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-22T22:21:42Z","subjects":["Materials Science and Engineering."],"languages":["eng"],"rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/119068","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Michael S. Strano."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. 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They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/119068"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.","Cataloged from PDF version of thesis.","Includes bibliographical references (pages 32-34)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.B."]},{"key":"dc:title","label":"Title","values":["Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Michael S. Strano."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Materials Science and Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Materials Science and Engineering."],"dc:creator":["Sun, Jessica H"],"dc:date.accessioned":["2018-11-15T16:35:12Z"],"dc:date.available":["2018-11-15T16:35:12Z"],"dc:date.issued":["2018"],"dc:description":["Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.","Cataloged from PDF version of thesis.","Includes bibliographical references (pages 32-34)."],"dc:description.abstract":["Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil."],"dc:description.degree":["S.B."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/119068"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Materials Science and Engineering."],"dc:title":["Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:21:42Z"}