{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/112447"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/112447","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Design of PolyMOCs and the synthesis of crosslinkers for the BASP platform","abstract":"In Chapter 1, two stepwise assembly strategies for the integration of metal-organic cages (MOCs) into polymers were explored. The first strategy creates Block Co-PolyMOCs (BCPMOCs), which feature the integration of MOCs into block copolymers (BCPs). In the first assembly step, BCPs functionalized with a bispyridyl ligand on the chain end undergo Pd induced MOC assembly. In the second step, microphase separation of BCPs is induced, introducing a physical cross-link between the star polymers and producing the desired BCPMOC networks in the bulk or gel state. In the second strategy, another orthogonal interaction is explored to create a different type of polyMOC. In this case, poly(methyl acrylate) (PMA) homopolymers are synthesized from initiators featuring a diene or dienophile on one end and functionalized with a bispyridyl ligand on the other end. Diels-Alder (DA) cycloaddition is used in the second step to create a polyMOC network. Given the functional diversity of MOCs, both strategies should enable access to materials with a wide range of properties and applications. Chapter 2 outlines the synthesis of norbornene macromonomers (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers that are acid- and photo-labile contributes to the expansion of a wide-ranging library of crosslinkers for drug loading and release. The brush-first ROMP polymerization strategy allows for the synthesis of BASPs for single drug or multiple drug combinations.","abstract_html":"In Chapter 1, two stepwise assembly strategies for the integration of metal-organic cages (MOCs) into polymers were explored. The first strategy creates Block Co-PolyMOCs (BCPMOCs), which feature the integration of MOCs into block copolymers (BCPs). In the first assembly step, BCPs functionalized with a bispyridyl ligand on the chain end undergo Pd induced MOC assembly. In the second step, microphase separation of BCPs is induced, introducing a physical cross-link between the star polymers and producing the desired BCPMOC networks in the bulk or gel state. In the second strategy, another orthogonal interaction is explored to create a different type of polyMOC. In this case, poly(methyl acrylate) (PMA) homopolymers are synthesized from initiators featuring a diene or dienophile on one end and functionalized with a bispyridyl ligand on the other end. Diels-Alder (DA) cycloaddition is used in the second step to create a polyMOC network. Given the functional diversity of MOCs, both strategies should enable access to materials with a wide range of properties and applications. Chapter 2 outlines the synthesis of norbornene macromonomers (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers that are acid- and photo-labile contributes to the expansion of a wide-ranging library of crosslinkers for drug loading and release. The brush-first ROMP polymerization strategy allows for the synthesis of BASPs for single drug or multiple drug combinations.","abstract_has_math":false,"creators":["Park, Jiwon Victoria"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Chemistry.","school":null,"contributors":[],"advisors":["Jeremiah A. Johnson."],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017","date_published":"2017","updated_at":"2026-07-22T22:22:13Z","subjects":["Chemistry."],"languages":["eng"],"rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/112447","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Jeremiah A. Johnson."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. Department of Chemistry."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Massachusetts Institute of Technology. Department of Chemistry."]},{"key":"dc:creator","label":"Author","values":["Park, Jiwon Victoria"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-12-05T19:13:13Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-12-05T19:13:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2017"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/112447"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis: S.B., Massachusetts Institute of Technology, Department of Chemistry, 2017.","Cataloged from PDF version of thesis.","Includes bibliographical references (pages 33-34)."]},{"key":"dc:description.abstract","label":"Abstract","values":["In Chapter 1, two stepwise assembly strategies for the integration of metal-organic cages (MOCs) into polymers were explored. The first strategy creates Block Co-PolyMOCs (BCPMOCs), which feature the integration of MOCs into block copolymers (BCPs). In the first assembly step, BCPs functionalized with a bispyridyl ligand on the chain end undergo Pd induced MOC assembly. In the second step, microphase separation of BCPs is induced, introducing a physical cross-link between the star polymers and producing the desired BCPMOC networks in the bulk or gel state. In the second strategy, another orthogonal interaction is explored to create a different type of polyMOC. In this case, poly(methyl acrylate) (PMA) homopolymers are synthesized from initiators featuring a diene or dienophile on one end and functionalized with a bispyridyl ligand on the other end. Diels-Alder (DA) cycloaddition is used in the second step to create a polyMOC network. Given the functional diversity of MOCs, both strategies should enable access to materials with a wide range of properties and applications. Chapter 2 outlines the synthesis of norbornene macromonomers (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers that are acid- and photo-labile contributes to the expansion of a wide-ranging library of crosslinkers for drug loading and release. The brush-first ROMP polymerization strategy allows for the synthesis of BASPs for single drug or multiple drug combinations."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.B."]},{"key":"dc:title","label":"Title","values":["Design of PolyMOCs and the synthesis of crosslinkers for the BASP platform"]}]}],"canonical_facts":{"dc:contributor.advisor":["Jeremiah A. Johnson."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Chemistry."],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Chemistry."],"dc:creator":["Park, Jiwon Victoria"],"dc:date.accessioned":["2017-12-05T19:13:13Z"],"dc:date.available":["2017-12-05T19:13:13Z"],"dc:date.issued":["2017"],"dc:description":["Thesis: S.B., Massachusetts Institute of Technology, Department of Chemistry, 2017.","Cataloged from PDF version of thesis.","Includes bibliographical references (pages 33-34)."],"dc:description.abstract":["In Chapter 1, two stepwise assembly strategies for the integration of metal-organic cages (MOCs) into polymers were explored. The first strategy creates Block Co-PolyMOCs (BCPMOCs), which feature the integration of MOCs into block copolymers (BCPs). In the first assembly step, BCPs functionalized with a bispyridyl ligand on the chain end undergo Pd induced MOC assembly. In the second step, microphase separation of BCPs is induced, introducing a physical cross-link between the star polymers and producing the desired BCPMOC networks in the bulk or gel state. In the second strategy, another orthogonal interaction is explored to create a different type of polyMOC. In this case, poly(methyl acrylate) (PMA) homopolymers are synthesized from initiators featuring a diene or dienophile on one end and functionalized with a bispyridyl ligand on the other end. Diels-Alder (DA) cycloaddition is used in the second step to create a polyMOC network. Given the functional diversity of MOCs, both strategies should enable access to materials with a wide range of properties and applications. Chapter 2 outlines the synthesis of norbornene macromonomers (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers that are acid- and photo-labile contributes to the expansion of a wide-ranging library of crosslinkers for drug loading and release. The brush-first ROMP polymerization strategy allows for the synthesis of BASPs for single drug or multiple drug combinations."],"dc:description.degree":["S.B."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/112447"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Chemistry."],"dc:title":["Design of PolyMOCs and the synthesis of crosslinkers for the BASP platform"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:22:13Z"}