Synthesis and characterization of magnetic nanorings for neuronal stimulation

Magnetic nanorings (MNRs) are anisotropic nanomaterials that can support a magnetic vortex state, which can yield both colloidal stability and large hysteretic power losses when exposed to an alternating magnetic field (AMF). Coupled with the biocompatibility of polymer surface coatings, MNRs have the potential of being used for many biological applications, including neuronal stimulation, drug delivery, and cancer hyperthermia. In this work, we synthesized varying geometries of MNRs via a thermal decomposition route and characterize their structural, chemical, and magnetothermal properties. Scanning and transmission electron microscopy was used to analyze surface morphology and geometry of nanostructures. X-ray diffraction allowed for differentiation of paramagnetic and ferrimagentic phases of synthesized iron oxide. Vibrating scanning magnetometry and induced coupled plasma atomic emission spectroscopy were used to determine magnetic properties, including saturation magnetization (Ms) and coercive field (He). Finally, calorimetric measurements were performed to calculate specific power losses (SLPs) of varying compositions of MNRs. We demonstrate that MNRs exhibit hysteretic power loss and can be optimized for neuronal stimulation under biologically safe AMF conditions.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Materials Science and Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2017

Author dc:creator

• Garcia, Francisco J.(Materials scientist) Massachusetts Institute of Technology

Advisor dc:contributor.advisor

• Polina Anikeeva.

• Materials Science and Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/111345

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/111345