{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/107506"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/107506","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Decoding the secret to faster drug production through simulation modeling","abstract":"For many manufacturing facilities, process improvement efforts are a luxury when faced with heightened competitive pressures and a fast-paced work environment where fires are constantly being fought. This need for speed is even more important for startup companies who are racing against time to get their product to the market. Continuous improvement and Lean projects typically span from trial-and-error experiments to changes based on lengthy analyses. Biotech startup Company XYZ has felt the effects of these forces and launched a new effort to improve its operations via continuous improvement and Lean, ultimately reducing costs and improving productivity of operations. This thesis examines one example of a process improvement effort at Company XYZ's pre-clinical manufacturing facility. This project involved characterizing the cycle time and process flow, leading to targeted actions to increase the throughput and reduce the amount of time and effort to manufacture their drugs. Tools and ideas from Lean and Six Sigma were applied and a recommendation and next steps were presented to the company. This thesis also provides a broader demonstration of how such continuous improvement efforts can fit into the pharmaceutical and biotechnology industries.","abstract_html":"For many manufacturing facilities, process improvement efforts are a luxury when faced with heightened competitive pressures and a fast-paced work environment where fires are constantly being fought. This need for speed is even more important for startup companies who are racing against time to get their product to the market. Continuous improvement and Lean projects typically span from trial-and-error experiments to changes based on lengthy analyses. Biotech startup Company XYZ has felt the effects of these forces and launched a new effort to improve its operations via continuous improvement and Lean, ultimately reducing costs and improving productivity of operations. This thesis examines one example of a process improvement effort at Company XYZ's pre-clinical manufacturing facility. This project involved characterizing the cycle time and process flow, leading to targeted actions to increase the throughput and reduce the amount of time and effort to manufacture their drugs. Tools and ideas from Lean and Six Sigma were applied and a recommendation and next steps were presented to the company. This thesis also provides a broader demonstration of how such continuous improvement efforts can fit into the pharmaceutical and biotechnology industries.","abstract_has_math":false,"creators":["Tsai, Mimi L"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Supply Chain Management Program.","school":null,"contributors":[],"advisors":["Bruce C. 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