LesionAir : a low-cost tool for automated skin cancer diagnosis and mapping

Skin cancer is the most common form of cancer in the United States; one out of every five Americans develops skin cancer at some point in their lifetime. Diagnosing cancerous lesions early is critical as it significantly increases the chance of survival. However, current techniques for diagnosing skin cancer lack specificity and sensitivity, resulting in many unnecessary biopsies and missed diagnoses. Although some researchers have increased diagnostic efficacy by quantitatively diagnosing skin cancer in an automated fashion, these methods require extremely bulky, expensive, and complicated equipment. This thesis presents the design and testing of LesionAir, a small, low-cost skin cancer diagnostic tool that measures the full-field compliance of the skin - which is well known to correlate strongly with skin cancer - by applying a vacuum force to the tissue and measuring precise deflection using structured light 3D reconstruction. Image processing algorithms determine additional morphological information about the potentially cancerous lesion. A pilot study of ten patients with suspect lesions validated LesionAir's effectiveness. After biopsy and analysis, a dermatopathologist confirmed the diagnosis of skin cancer in tissue that LesionAir identified as noticeably stiffer, and the regions of this stiffened tissue aligned nearly perfectly with the bounds established by the histological tests, which showed the method determines the precise coordinates that must be excised to safely remove all cancerous tissue. This technology can thus enable patients, primary care physicians, and dermatologists to rapidly identify and diagnose skin cancer with diagnostic quality not seen before from any equipment in this class.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2016

Author dc:creator

• Wortman, Tyler David

Advisor dc:contributor.advisor

• Alexander H. Slocum.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/104499

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/104499