{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/96171"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/96171","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites","abstract":"Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study compared NT-proBNP and cTnI concentrations, as well as POCUS findings in dogs presenting with cNHA and ncNHA. Animals: Dogs (n=60) were enrolled based on identification of NHA with an effusion PCV < 10 percent. Methods: Blood samples were collected, and POCUS performed on all dogs. Dogs were diagnosed with cNHA (n=28) or ncNHA (n=32) based on echocardiography. The cNHA group was subdivided into cardiac non-pericardial disease (n=17) and pericardial disease (n=11). Results: The NT-proBNP concentration (mean[plus or minus]SD pmol/L) was significantly higher in the cNHA group (4869[plus or minus]4078) compared with the ncNHA group (1882[plus or minus]2627) (p=0.022), with a sensitivity of 53.8 percent and specificity of 85.7 percent using a cut-off of 4092 pmol/L. The NT-proBNP concentrations were significantly higher in the cardiac non-pericardial disease group (7177[plus or minus]3435) compared with the pericardial disease group (1179[plus or minus]1398) (p < 0.0001). A significant difference in cTnI concentration (mean[plus or minus]SD ng/L) between the cNHA group (6522[plus or minus]23186) and ncNHA group (1701[plus or minus]7040) was not detected (p=0.3). A significantly higher number of dogs had hepatic venous and CaVC distension in the cNHA group compared with the ncNHA group respectively (18/28 vs 3/29, p < 0.0001 and 13/27 vs 2/29, p < 0.001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, p=0.74). Conclusions and clinical importance: NT-proBNP and POCUS help distinguish between cNHA and ncNHA.","abstract_html":"Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study compared NT-proBNP and cTnI concentrations, as well as POCUS findings in dogs presenting with cNHA and ncNHA. Animals: Dogs (n=60) were enrolled based on identification of NHA with an effusion PCV &lt; 10 percent. Methods: Blood samples were collected, and POCUS performed on all dogs. Dogs were diagnosed with cNHA (n=28) or ncNHA (n=32) based on echocardiography. The cNHA group was subdivided into cardiac non-pericardial disease (n=17) and pericardial disease (n=11). Results: The NT-proBNP concentration (mean[plus or minus]SD pmol/L) was significantly higher in the cNHA group (4869[plus or minus]4078) compared with the ncNHA group (1882[plus or minus]2627) (p=0.022), with a sensitivity of 53.8 percent and specificity of 85.7 percent using a cut-off of 4092 pmol/L. The NT-proBNP concentrations were significantly higher in the cardiac non-pericardial disease group (7177[plus or minus]3435) compared with the pericardial disease group (1179[plus or minus]1398) (p &lt; 0.0001). A significant difference in cTnI concentration (mean[plus or minus]SD ng/L) between the cNHA group (6522[plus or minus]23186) and ncNHA group (1701[plus or minus]7040) was not detected (p=0.3). A significantly higher number of dogs had hepatic venous and CaVC distension in the cNHA group compared with the ncNHA group respectively (18/28 vs 3/29, p &lt; 0.0001 and 13/27 vs 2/29, p &lt; 0.001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, p=0.74). Conclusions and clinical importance: NT-proBNP and POCUS help distinguish between cNHA and ncNHA.","abstract_has_math":false,"creators":["Morey, Alice Georgina Nekesa"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Biomedical Sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Leach, Stacey"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-24T03:07:35Z","subjects":[],"languages":["eng","English"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/96171"],"render_values":[{"text":"https://doi.org/10.32469/10355/96171","href":"https://doi.org/10.32469/10355/96171","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/96171","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Leach, Stacey"]},{"key":"dc:creator","label":"Author","values":["Morey, Alice Georgina Nekesa"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2023-08-01T19:13:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2023-08-01T19:13:39Z"]},{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/96171"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/96171"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study compared NT-proBNP and cTnI concentrations, as well as POCUS findings in dogs presenting with cNHA and ncNHA. Animals: Dogs (n=60) were enrolled based on identification of NHA with an effusion PCV < 10 percent. Methods: Blood samples were collected, and POCUS performed on all dogs. Dogs were diagnosed with cNHA (n=28) or ncNHA (n=32) based on echocardiography. The cNHA group was subdivided into cardiac non-pericardial disease (n=17) and pericardial disease (n=11). Results: The NT-proBNP concentration (mean[plus or minus]SD pmol/L) was significantly higher in the cNHA group (4869[plus or minus]4078) compared with the ncNHA group (1882[plus or minus]2627) (p=0.022), with a sensitivity of 53.8 percent and specificity of 85.7 percent using a cut-off of 4092 pmol/L. The NT-proBNP concentrations were significantly higher in the cardiac non-pericardial disease group (7177[plus or minus]3435) compared with the pericardial disease group (1179[plus or minus]1398) (p < 0.0001). A significant difference in cTnI concentration (mean[plus or minus]SD ng/L) between the cNHA group (6522[plus or minus]23186) and ncNHA group (1701[plus or minus]7040) was not detected (p=0.3). A significantly higher number of dogs had hepatic venous and CaVC distension in the cNHA group compared with the ncNHA group respectively (18/28 vs 3/29, p < 0.0001 and 13/27 vs 2/29, p < 0.001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, p=0.74). Conclusions and clinical importance: NT-proBNP and POCUS help distinguish between cNHA and ncNHA."]},{"key":"dc:title","label":"Title","values":["Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites"]}]}],"canonical_facts":{"dc:contributor.advisor":["Leach, Stacey"],"dc:creator":["Morey, Alice Georgina Nekesa"],"dc:date.accessioned":["2023-08-01T19:13:39Z"],"dc:date.available":["2023-08-01T19:13:39Z"],"dc:date.issued":["2023"],"dc:description.abstract":["Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study compared NT-proBNP and cTnI concentrations, as well as POCUS findings in dogs presenting with cNHA and ncNHA. Animals: Dogs (n=60) were enrolled based on identification of NHA with an effusion PCV < 10 percent. Methods: Blood samples were collected, and POCUS performed on all dogs. Dogs were diagnosed with cNHA (n=28) or ncNHA (n=32) based on echocardiography. The cNHA group was subdivided into cardiac non-pericardial disease (n=17) and pericardial disease (n=11). Results: The NT-proBNP concentration (mean[plus or minus]SD pmol/L) was significantly higher in the cNHA group (4869[plus or minus]4078) compared with the ncNHA group (1882[plus or minus]2627) (p=0.022), with a sensitivity of 53.8 percent and specificity of 85.7 percent using a cut-off of 4092 pmol/L. The NT-proBNP concentrations were significantly higher in the cardiac non-pericardial disease group (7177[plus or minus]3435) compared with the pericardial disease group (1179[plus or minus]1398) (p < 0.0001). A significant difference in cTnI concentration (mean[plus or minus]SD ng/L) between the cNHA group (6522[plus or minus]23186) and ncNHA group (1701[plus or minus]7040) was not detected (p=0.3). A significantly higher number of dogs had hepatic venous and CaVC distension in the cNHA group compared with the ncNHA group respectively (18/28 vs 3/29, p < 0.0001 and 13/27 vs 2/29, p < 0.001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, p=0.74). Conclusions and clinical importance: NT-proBNP and POCUS help distinguish between cNHA and ncNHA."],"dc:identifier.doi":["https://doi.org/10.32469/10355/96171"],"dc:identifier.uri":["https://hdl.handle.net/10355/96171"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:title":["Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites"],"dc:type":["Thesis"],"thesis:degree_discipline":["Biomedical Sciences (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:07:35Z"}