A novel approach for treating resistant hypertension using a controlled-pump accumulator relief device

Hypertension contributes to cardiovascular morbidity and mortality worldwide. While many hypertensive patients respond to drug therapy, a growing number of these cases are called resistant hypertension (RH), when patients cannot control their blood pressure to goal levels despite the use of multiple antihypertensive medications. While current interventional treatments for RH are based on dealing with the nervous system, there is no existing procedure that considers altering the way in which blood is pumped into the aorta such that to reduce blood pressure. We hypothesize that RH may be controlled by altering the way in which blood is pumped into the aorta. We introduce a novel idea of implementing what we called the accumulator device, which may be classified as a mechanical assist device for the cardiac system. A lumped-parameter model describing the cardiovascular system is presented and validated. The novel idea of accumulator device is also modeled and incorporated with the cardiovascular system model using analogies between the circulatory system, hydraulic systems, and electric circuits. The simulation work of the proposed accumulator device idea reveals promising preliminary results. It shows an ability to significantly decrease the systolic pressure by regulating the way in which blood is pumped into the aorta during the cardiac cycle, without reducing the cardiac output. It is our hope that this novel approach provides a transformational alternative to existing methods for treating RH, becomes a successful treatment option in the future, and improves life for millions of RH patients.

Name thesis:degree_name

Ph. D.

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Electrical and computer engineering (MU)

Grantor dc:publisher

University of Missouri--Columbia

Year dc:date.issued

2018

Author dc:creator

• Alturki, Adel M.

Advisor dc:contributor.advisor

• Manring, Noah D.

Statement dc:rights

• OpenAccess.

Language dc:language.iso

eng, English

DOI

https://doi.org/10.32469/10355/68882

OAI identifier oai:identifier

oai:mospace.umsystem.edu:10355/68882