{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/6103"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/6103","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids","abstract":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to the extensively studied nucleus accumbens opiate-induced feeding behavior. The present study investigated the intra-NAcc effects of selective A1 and A2A adenosine receptor ligands alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. CCPA had no effect on baseline or DAMGO-induced feeding or activity, while CGS 21680 decreased baseline activity but had no effect on feeding. DPX decreased feeding alone, while having no effect on activity. MSX-3 produced both robust feeding and activity increases and facilitated DAMGO-induced behaviors. These effects were blocked by naltrexone. Overall, it was observed that manipulation of A2A receptors produced stronger modulatory effects than A1 receptor manipulation on consumption, both alone and when co-administered with DAMGO. Indeed, it is expected that A2A receptors, being more densely localized throughout the accumbens, would have a greater impact on behaviors mediated by the nucleus accumbens than A1 receptors. In summary, these results suggest an intriguing role for striatal adenosine in mediating baseline and striatal opioid-mediated behaviors.","abstract_html":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to the extensively studied nucleus accumbens opiate-induced feeding behavior. The present study investigated the intra-NAcc effects of selective A1 and A2A adenosine receptor ligands alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. CCPA had no effect on baseline or DAMGO-induced feeding or activity, while CGS 21680 decreased baseline activity but had no effect on feeding. DPX decreased feeding alone, while having no effect on activity. MSX-3 produced both robust feeding and activity increases and facilitated DAMGO-induced behaviors. These effects were blocked by naltrexone. Overall, it was observed that manipulation of A2A receptors produced stronger modulatory effects than A1 receptor manipulation on consumption, both alone and when co-administered with DAMGO. Indeed, it is expected that A2A receptors, being more densely localized throughout the accumbens, would have a greater impact on behaviors mediated by the nucleus accumbens than A1 receptors. In summary, these results suggest an intriguing role for striatal adenosine in mediating baseline and striatal opioid-mediated behaviors.","abstract_has_math":false,"creators":["Pritchett Kelley, Carolyn Elisabeth"],"institution":"University of Missouri--Columbia","degree_name":"M.A.","degree_level":"Masters","degree_discipline":"Psychological sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Will, Matthew J."],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-24T03:08:43Z","subjects":[],"languages":["eng","English"],"rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/6103"],"render_values":[{"text":"https://doi.org/10.32469/10355/6103","href":"https://doi.org/10.32469/10355/6103","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/6103","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Will, Matthew J."]},{"key":"dc:creator","label":"Author","values":["Pritchett Kelley, Carolyn Elisabeth"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-02-24T19:43:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-02-24T19:43:43Z"]},{"key":"dc:date.issued","label":"Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychological sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.A."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Access to files is limited to the campuses of the University of Missouri with SSO login."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/6103"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/6103"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on August 21, 2009)","Includes bibliographical references.","Thesis (M.A.) University of Missouri-Columbia 2008.","Dissertations, Academic -- University of Missouri--Columbia -- Psychology."]},{"key":"dc:description.abstract","label":"Abstract","values":["[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to the extensively studied nucleus accumbens opiate-induced feeding behavior. The present study investigated the intra-NAcc effects of selective A1 and A2A adenosine receptor ligands alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. CCPA had no effect on baseline or DAMGO-induced feeding or activity, while CGS 21680 decreased baseline activity but had no effect on feeding. DPX decreased feeding alone, while having no effect on activity. MSX-3 produced both robust feeding and activity increases and facilitated DAMGO-induced behaviors. These effects were blocked by naltrexone. Overall, it was observed that manipulation of A2A receptors produced stronger modulatory effects than A1 receptor manipulation on consumption, both alone and when co-administered with DAMGO. Indeed, it is expected that A2A receptors, being more densely localized throughout the accumbens, would have a greater impact on behaviors mediated by the nucleus accumbens than A1 receptors. In summary, these results suggest an intriguing role for striatal adenosine in mediating baseline and striatal opioid-mediated behaviors."]},{"key":"dc:title","label":"Title","values":["Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids"]}]}],"canonical_facts":{"dc:contributor.advisor":["Will, Matthew J."],"dc:creator":["Pritchett Kelley, Carolyn Elisabeth"],"dc:date.accessioned":["2010-02-24T19:43:43Z"],"dc:date.available":["2010-02-24T19:43:43Z"],"dc:date.issued":["2008"],"dc:description":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on August 21, 2009)","Includes bibliographical references.","Thesis (M.A.) University of Missouri-Columbia 2008.","Dissertations, Academic -- University of Missouri--Columbia -- Psychology."],"dc:description.abstract":["[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine receptors differently contribute to the extensively studied nucleus accumbens opiate-induced feeding behavior. The present study investigated the intra-NAcc effects of selective A1 and A2A adenosine receptor ligands alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. CCPA had no effect on baseline or DAMGO-induced feeding or activity, while CGS 21680 decreased baseline activity but had no effect on feeding. DPX decreased feeding alone, while having no effect on activity. MSX-3 produced both robust feeding and activity increases and facilitated DAMGO-induced behaviors. These effects were blocked by naltrexone. Overall, it was observed that manipulation of A2A receptors produced stronger modulatory effects than A1 receptor manipulation on consumption, both alone and when co-administered with DAMGO. Indeed, it is expected that A2A receptors, being more densely localized throughout the accumbens, would have a greater impact on behaviors mediated by the nucleus accumbens than A1 receptors. In summary, these results suggest an intriguing role for striatal adenosine in mediating baseline and striatal opioid-mediated behaviors."],"dc:identifier.doi":["https://doi.org/10.32469/10355/6103"],"dc:identifier.uri":["https://hdl.handle.net/10355/6103"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"dc:title":["Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids"],"dc:type":["Thesis"],"thesis:degree_discipline":["Psychological sciences (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.A."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:08:43Z"}