{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/5619"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/5619","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells","abstract":"Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth.","abstract_html":"Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth.","abstract_has_math":false,"creators":["Xu, Tongtong, 1977-"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Plant sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Song, Qisheng"],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-24T03:07:46Z","subjects":[],"languages":["eng","English"],"rights":["OpenAccess."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/5619"],"render_values":[{"text":"https://doi.org/10.32469/10355/5619","href":"https://doi.org/10.32469/10355/5619","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/5619","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Song, Qisheng"]},{"key":"dc:creator","label":"Author","values":["Xu, Tongtong, 1977-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-02-23T17:12:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-02-23T17:12:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Plant sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["OpenAccess."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/5619"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/5619"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on July 9, 2009)","Thesis (M.S.) University of Missouri-Columbia 2008."]},{"key":"dc:description.abstract","label":"Abstract","values":["Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth."]},{"key":"dc:title","label":"Title","values":["Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells"]}]}],"canonical_facts":{"dc:contributor.advisor":["Song, Qisheng"],"dc:creator":["Xu, Tongtong, 1977-"],"dc:date.accessioned":["2010-02-23T17:12:30Z"],"dc:date.available":["2010-02-23T17:12:30Z"],"dc:date.issued":["2008"],"dc:description":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on July 9, 2009)","Thesis (M.S.) University of Missouri-Columbia 2008."],"dc:description.abstract":["Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth."],"dc:identifier.doi":["https://doi.org/10.32469/10355/5619"],"dc:identifier.uri":["https://hdl.handle.net/10355/5619"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["OpenAccess."],"dc:title":["Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells"],"dc:type":["Thesis"],"thesis:degree_discipline":["Plant sciences (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:07:46Z"}