{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/5030"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/5030","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Modeling of phototransduction in vision systems","abstract":"To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of differential equations were derived to predict the electrical response of photoreceptors to light and system identification was employed to determine the model parameters. When applied to wild-type and retina-damaged mice, the proposed model effectively described the ERG a-wave over a range of light intensities and different stimulus patterns. From the model parameters, the retina-damaged subjects could be differentiated from the normal ones. It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. It also provides insights into dynamics of the vision system.","abstract_html":"To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of differential equations were derived to predict the electrical response of photoreceptors to light and system identification was employed to determine the model parameters. When applied to wild-type and retina-damaged mice, the proposed model effectively described the ERG a-wave over a range of light intensities and different stimulus patterns. From the model parameters, the retina-damaged subjects could be differentiated from the normal ones. It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. It also provides insights into dynamics of the vision system.","abstract_has_math":false,"creators":["Lu, Lei, 1968-"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Biological engineering (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Tan, Jinglu, 1958-"],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-24T03:07:24Z","subjects":["phototransduction; vision system.","phototransduction; vision system"],"languages":["eng","English"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/5030"],"render_values":[{"text":"https://doi.org/10.32469/10355/5030","href":"https://doi.org/10.32469/10355/5030","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/5030","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Tan, Jinglu, 1958-"]},{"key":"dc:creator","label":"Author","values":["Lu, Lei, 1968-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-01-12T19:08:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-01-12T19:08:38Z"]},{"key":"dc:date.issued","label":"Date","values":["2007"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biological engineering (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["phototransduction; vision system.","phototransduction; vision system"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/5030"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/5030"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on April 1, 2008)","Includes bibliographical references.","Thesis (M.S.) 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It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. 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