{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/45840"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/45840","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Fabrication of a novel radiopharmaceutical: lutetium-177 loaded MCM-41mesoporous silica","abstract":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted therapy of cancer, by binding the radionuclide with a carrier agent, provides more accurate delivery to focal tumor cell with low uptake in normal organs. In this paper, a new radio-loaded nanoparticle has been explored. A method for loading [superscript 177]Lu into MCM-41 was evaluated by varying starting material and loading reaction factors. For the procedure of [superscript 177]Lu loaded MCM-41, cetyltrimethylammonium bromide was dissolved in a solution of 384 ml of MilliQ water heated at 45[degree sign]C and then 2 M NaOH aqueous solution was added. The mixture was stirred vigorously at 80[degree sign]C for 0.5 h. Then tetraethylorthosilicate was added dropwise with vigorous stirring for another 2 h, followed by filtration and drying in the oven at 100 [degree sign]C for 12 h. Grounded powder was calcined in furnace at 550 ?C for 5 hours to remove the surfactant. And then MCM-41 solution was prepared by its fine powder in MilliQ water to give a concentration of 50 mg/ml. The reaction mixture consisted of a 150 [micro]l aliquot of the stock solution containing 20 [micro]g MCM-41(0.2669 mmol) and 150 [micro]l of [superscript 177]LuCl[subscript 3] solution (76.5 MBq) to which was then added 500 [micro]l of 0.01 M LaCl3 ?5 ?mol) mixed at room temperature and then 1 M NaOH was added to reach pH =6.5 for 1 hour. This novel synthesis method shows an over 99 % loading percentage of [superscript 177]Lu-MCM-41.","abstract_html":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted therapy of cancer, by binding the radionuclide with a carrier agent, provides more accurate delivery to focal tumor cell with low uptake in normal organs. In this paper, a new radio-loaded nanoparticle has been explored. A method for loading [superscript 177]Lu into MCM-41 was evaluated by varying starting material and loading reaction factors. For the procedure of [superscript 177]Lu loaded MCM-41, cetyltrimethylammonium bromide was dissolved in a solution of 384 ml of MilliQ water heated at 45[degree sign]C and then 2 M NaOH aqueous solution was added. The mixture was stirred vigorously at 80[degree sign]C for 0.5 h. Then tetraethylorthosilicate was added dropwise with vigorous stirring for another 2 h, followed by filtration and drying in the oven at 100 [degree sign]C for 12 h. Grounded powder was calcined in furnace at 550 ?C for 5 hours to remove the surfactant. And then MCM-41 solution was prepared by its fine powder in MilliQ water to give a concentration of 50 mg/ml. The reaction mixture consisted of a 150 [micro]l aliquot of the stock solution containing 20 [micro]g MCM-41(0.2669 mmol) and 150 [micro]l of [superscript 177]LuCl[subscript 3] solution (76.5 MBq) to which was then added 500 [micro]l of 0.01 M LaCl3 ?5 ?mol) mixed at room temperature and then 1 M NaOH was added to reach pH =6.5 for 1 hour. This novel synthesis method shows an over 99 % loading percentage of [superscript 177]Lu-MCM-41.","abstract_has_math":false,"creators":["Li, Mingda"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Chemical engineering (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Gahl, John M. (John Michel)","Culter, Cathy"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-24T03:08:32Z","subjects":[],"languages":["eng","English"],"rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10355/45840","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gahl, John M. 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In this paper, a new radio-loaded nanoparticle has been explored. A method for loading [superscript 177]Lu into MCM-41 was evaluated by varying starting material and loading reaction factors. For the procedure of [superscript 177]Lu loaded MCM-41, cetyltrimethylammonium bromide was dissolved in a solution of 384 ml of MilliQ water heated at 45[degree sign]C and then 2 M NaOH aqueous solution was added. The mixture was stirred vigorously at 80[degree sign]C for 0.5 h. Then tetraethylorthosilicate was added dropwise with vigorous stirring for another 2 h, followed by filtration and drying in the oven at 100 [degree sign]C for 12 h. Grounded powder was calcined in furnace at 550 ?C for 5 hours to remove the surfactant. And then MCM-41 solution was prepared by its fine powder in MilliQ water to give a concentration of 50 mg/ml. The reaction mixture consisted of a 150 [micro]l aliquot of the stock solution containing 20 [micro]g MCM-41(0.2669 mmol) and 150 [micro]l of [superscript 177]LuCl[subscript 3] solution (76.5 MBq) to which was then added 500 [micro]l of 0.01 M LaCl3 ?5 ?mol) mixed at room temperature and then 1 M NaOH was added to reach pH =6.5 for 1 hour. This novel synthesis method shows an over 99 % loading percentage of [superscript 177]Lu-MCM-41."]},{"key":"dc:title","label":"Title","values":["Fabrication of a novel radiopharmaceutical: lutetium-177 loaded MCM-41mesoporous silica"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gahl, John M. (John Michel)","Culter, Cathy"],"dc:creator":["Li, Mingda"],"dc:date.accessioned":["2015-06-03T13:50:42Z"],"dc:date.available":["2015-06-03T13:50:42Z"],"dc:date.issued":["2014"],"dc:description.abstract":["[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted therapy of cancer, by binding the radionuclide with a carrier agent, provides more accurate delivery to focal tumor cell with low uptake in normal organs. In this paper, a new radio-loaded nanoparticle has been explored. A method for loading [superscript 177]Lu into MCM-41 was evaluated by varying starting material and loading reaction factors. For the procedure of [superscript 177]Lu loaded MCM-41, cetyltrimethylammonium bromide was dissolved in a solution of 384 ml of MilliQ water heated at 45[degree sign]C and then 2 M NaOH aqueous solution was added. The mixture was stirred vigorously at 80[degree sign]C for 0.5 h. Then tetraethylorthosilicate was added dropwise with vigorous stirring for another 2 h, followed by filtration and drying in the oven at 100 [degree sign]C for 12 h. Grounded powder was calcined in furnace at 550 ?C for 5 hours to remove the surfactant. And then MCM-41 solution was prepared by its fine powder in MilliQ water to give a concentration of 50 mg/ml. The reaction mixture consisted of a 150 [micro]l aliquot of the stock solution containing 20 [micro]g MCM-41(0.2669 mmol) and 150 [micro]l of [superscript 177]LuCl[subscript 3] solution (76.5 MBq) to which was then added 500 [micro]l of 0.01 M LaCl3 ?5 ?mol) mixed at room temperature and then 1 M NaOH was added to reach pH =6.5 for 1 hour. This novel synthesis method shows an over 99 % loading percentage of [superscript 177]Lu-MCM-41."],"dc:identifier.uri":["https://hdl.handle.net/10355/45840"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"dc:title":["Fabrication of a novel radiopharmaceutical: lutetium-177 loaded MCM-41mesoporous silica"],"dc:type":["Thesis"],"thesis:degree_discipline":["Chemical engineering (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:08:32Z"}