A distributed CPU-GPU framework for large-scale pairwise alignment

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Several problems in computational biology require the all-against-all pairwise comparisons of tens of thousands of individual biological sequences. Each such comparison can be performed with the well-known Needleman-Wunsch alignment algorithm. However, with the rapid growth of biological databases, performing all possible comparisons with this algorithm in serial becomes extremely time-consuming. The massive computational power of graphics processing units (GPUs) makes them an appealing choice for accelerating these computations. As such, CPU-GPU clusters can enable all-against-all comparisons on large datasets. This thesis presents a hybrid MPI-CUDA framework for computing multiple pairwise sequence alignments on CPU-GPU clusters. The design targets both homogeneous and heterogeneous clusters with nodes characterized by different hardware and computing capabilities. The framework consists of the following components: a cluster-level dispatcher, a set of node-level dispatchers, and a set of CPU- and GPUworkers. The cluster-level dispatcher progressively distributes work to the compute nodes and aggregates the results. The node-level dispatchers distribute alignment tasks to available CPUs and GPUs and perform dual-buffering to hide data transfers between CPU and GPU. CPU- and GPU-workers perform pairwise sequence alignments using the Needleman-Wunsch algorithm. The proposed GPU workers are evaluated on different platforms and all of them outperform the existing open-source implementation from the Rodinia Benchmark Suite.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Computer engineering (MU)

Grantor dc:publisher

University of Missouri--Columbia

Year dc:date.issued

2014

Author dc:creator

• Li, Da

Advisor dc:contributor.advisor

• Becchi, Michela

• Author supplied: heterogenoous cluster, GPU, needleman-wunsch, CUDA

Statement dc:rights

• Access to files is limited to the University of Missouri--Columbia with SSO login.

Language dc:language.iso

eng, English

Handle dc:identifier.uri

https://hdl.handle.net/10355/44241

OAI identifier oai:identifier

oai:mospace.umsystem.edu:10355/44241