{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/44194"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/44194","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"The effects of leptin on placental development and function, and offspring behavior in mice","abstract":"The nutritional and energy status of individuals is communicated throughout the body by means of leptin. This hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine the importance of the leptin receptors of the mouse conceptus in placental development and function. We utilized a leptin receptor knockout mouse model, and found significant alterations in gene expression in placentas lacking the receptor, suggesting that placental function may be altered. The goal of the second study was to determine the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had reduced preference for palatable food compared to their controls. Maternal hyperleptinemia during pregnancy protected offspring from weight gain by increasing activity. Overall, leptin affects placental gene expression, and possibly function, and offspring behaviors that influence energy homeostasis.","abstract_html":"The nutritional and energy status of individuals is communicated throughout the body by means of leptin. This hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine the importance of the leptin receptors of the mouse conceptus in placental development and function. We utilized a leptin receptor knockout mouse model, and found significant alterations in gene expression in placentas lacking the receptor, suggesting that placental function may be altered. The goal of the second study was to determine the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had reduced preference for palatable food compared to their controls. Maternal hyperleptinemia during pregnancy protected offspring from weight gain by increasing activity. Overall, leptin affects placental gene expression, and possibly function, and offspring behaviors that influence energy homeostasis.","abstract_has_math":false,"creators":["Pollock, Kelly E., 1985-"],"institution":"University of Missouri--Columbia","degree_name":"Ph. D.","degree_level":"Doctoral","degree_discipline":"Animal sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Schulz, Laura Elizabeth"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-24T03:08:09Z","subjects":["Author supplied: Leptin; fetal programming; activity; feeding behavior"],"languages":["eng","English"],"rights":["OpenAccess."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/44194"],"render_values":[{"text":"https://doi.org/10.32469/10355/44194","href":"https://doi.org/10.32469/10355/44194","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/44194","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Schulz, Laura Elizabeth"]},{"key":"dc:creator","label":"Author","values":["Pollock, Kelly E., 1985-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-11-07T22:40:56Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-11-07T22:40:56Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Author supplied: Leptin; fetal programming; activity; feeding behavior"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["OpenAccess."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/44194"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/44194"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"May 2014.\"","Dissertation Supervisor: Dr. Laura Schulz.","Includes vita."]},{"key":"dc:description.abstract","label":"Abstract","values":["The nutritional and energy status of individuals is communicated throughout the body by means of leptin. This hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine the importance of the leptin receptors of the mouse conceptus in placental development and function. We utilized a leptin receptor knockout mouse model, and found significant alterations in gene expression in placentas lacking the receptor, suggesting that placental function may be altered. The goal of the second study was to determine the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had reduced preference for palatable food compared to their controls. Maternal hyperleptinemia during pregnancy protected offspring from weight gain by increasing activity. Overall, leptin affects placental gene expression, and possibly function, and offspring behaviors that influence energy homeostasis."]},{"key":"dc:source","label":"Dc Source","values":["Submitted by the University of Missouri--Columbia Graduate School"]},{"key":"dc:title","label":"Title","values":["The effects of leptin on placental development and function, and offspring behavior in mice"]}]}],"canonical_facts":{"dc:contributor.advisor":["Schulz, Laura Elizabeth"],"dc:creator":["Pollock, Kelly E., 1985-"],"dc:date.accessioned":["2014-11-07T22:40:56Z"],"dc:date.available":["2014-11-07T22:40:56Z"],"dc:date.issued":["2014"],"dc:description":["\"May 2014.\"","Dissertation Supervisor: Dr. Laura Schulz.","Includes vita."],"dc:description.abstract":["The nutritional and energy status of individuals is communicated throughout the body by means of leptin. This hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine the importance of the leptin receptors of the mouse conceptus in placental development and function. We utilized a leptin receptor knockout mouse model, and found significant alterations in gene expression in placentas lacking the receptor, suggesting that placental function may be altered. The goal of the second study was to determine the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had reduced preference for palatable food compared to their controls. Maternal hyperleptinemia during pregnancy protected offspring from weight gain by increasing activity. Overall, leptin affects placental gene expression, and possibly function, and offspring behaviors that influence energy homeostasis."],"dc:identifier.doi":["https://doi.org/10.32469/10355/44194"],"dc:identifier.uri":["https://hdl.handle.net/10355/44194"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["OpenAccess."],"dc:source":["Submitted by the University of Missouri--Columbia Graduate School"],"dc:subject":["Author supplied: Leptin; fetal programming; activity; feeding behavior"],"dc:title":["The effects of leptin on placental development and function, and offspring behavior in mice"],"dc:type":["Thesis"],"thesis:degree_discipline":["Animal sciences (MU)"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Ph. D."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:08:09Z"}