{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/4368"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/4368","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"The relationship between mitochondria and residual feed intake in feedlot cattle","abstract":"Residual feed intake (RFI) is a measure of feed efficiency that is not related to an animal's growth rate or body size. Little is known about the factors that affect RFI because, until recently, the measurement of RFI in large numbers of animals was not possible. Recently, researchers have shown a relationship in poultry between feed efficiency and measures of mitochondrial function and respiration. We hypothesized that a similar relationship existed in cattle. Steers were selected to have high or low RFI, the animals were scarified, and mitochondria were isolated from skeletal muscle. Low RFI steers had greater rates of state 2 and 3 respiration and produced more hydrogen peroxide. A blood assay was designed based on these findings to predict RFI status. The assay was able to detect differences between the high and low RFI groups; however it was not sensitive enough to correctly predict RFI status of individual animals.","abstract_html":"Residual feed intake (RFI) is a measure of feed efficiency that is not related to an animal's growth rate or body size. Little is known about the factors that affect RFI because, until recently, the measurement of RFI in large numbers of animals was not possible. Recently, researchers have shown a relationship in poultry between feed efficiency and measures of mitochondrial function and respiration. We hypothesized that a similar relationship existed in cattle. Steers were selected to have high or low RFI, the animals were scarified, and mitochondria were isolated from skeletal muscle. Low RFI steers had greater rates of state 2 and 3 respiration and produced more hydrogen peroxide. A blood assay was designed based on these findings to predict RFI status. The assay was able to detect differences between the high and low RFI groups; however it was not sensitive enough to correctly predict RFI status of individual animals.","abstract_has_math":false,"creators":["Kolath, William H., 1979-"],"institution":"University of Missouri--Columbia","degree_name":"Ph. 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Little is known about the factors that affect RFI because, until recently, the measurement of RFI in large numbers of animals was not possible. Recently, researchers have shown a relationship in poultry between feed efficiency and measures of mitochondrial function and respiration. We hypothesized that a similar relationship existed in cattle. Steers were selected to have high or low RFI, the animals were scarified, and mitochondria were isolated from skeletal muscle. Low RFI steers had greater rates of state 2 and 3 respiration and produced more hydrogen peroxide. A blood assay was designed based on these findings to predict RFI status. The assay was able to detect differences between the high and low RFI groups; however it was not sensitive enough to correctly predict RFI status of individual animals."]},{"key":"dc:title","label":"Title","values":["The relationship between mitochondria and residual feed intake in feedlot cattle"]}]}],"canonical_facts":{"dc:contributor.advisor":["Kerley, Monty Stephen, 1960-"],"dc:creator":["Kolath, William H., 1979-"],"dc:date.accessioned":["2010-01-12T17:05:53Z"],"dc:date.available":["2010-01-12T17:05:53Z"],"dc:date.issued":["2006"],"dc:description":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on April 27, 2009)","Vita.","Thesis (Ph.D.) University of Missouri-Columbia 2006."],"dc:description.abstract":["Residual feed intake (RFI) is a measure of feed efficiency that is not related to an animal's growth rate or body size. Little is known about the factors that affect RFI because, until recently, the measurement of RFI in large numbers of animals was not possible. Recently, researchers have shown a relationship in poultry between feed efficiency and measures of mitochondrial function and respiration. We hypothesized that a similar relationship existed in cattle. Steers were selected to have high or low RFI, the animals were scarified, and mitochondria were isolated from skeletal muscle. Low RFI steers had greater rates of state 2 and 3 respiration and produced more hydrogen peroxide. A blood assay was designed based on these findings to predict RFI status. 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