{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/4350"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/4350","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Specific bio-modeling and analysis techniques at cellular and systems level","abstract":"Modeling approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on prefrontal cortical cells are elucidated with two possible hypotheses, and a systematic methodology to study the excitability of cells under inhibitory post synaptic currents (IPSCs) is developed. PART II focuses on mathematical models at the systems level. Specifically, thermal physiology models of the entire human body are developed using statistical and black box (artificial neural network, ANN) techniques.The MU 2-D Man, a human thermal model has been developed for designing an automatic thermal comfort control strategy for NASA astronaut space suits and for the US Air Force warfighters in chemo-bio suits. The model has been enhanced using more accurate modeling of digits incorporating arterio-venous anastomoses (AVA) mechanisms that the fingers and toes use for better control of heat transfer.","abstract_html":"Modeling approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on prefrontal cortical cells are elucidated with two possible hypotheses, and a systematic methodology to study the excitability of cells under inhibitory post synaptic currents (IPSCs) is developed. PART II focuses on mathematical models at the systems level. Specifically, thermal physiology models of the entire human body are developed using statistical and black box (artificial neural network, ANN) techniques.The MU 2-D Man, a human thermal model has been developed for designing an automatic thermal comfort control strategy for NASA astronaut space suits and for the US Air Force warfighters in chemo-bio suits. The model has been enhanced using more accurate modeling of digits incorporating arterio-venous anastomoses (AVA) mechanisms that the fingers and toes use for better control of heat transfer.","abstract_has_math":false,"creators":["Jang, Tai Seung, 1971-"],"institution":"University of Missouri--Columbia","degree_name":"Ph. D.","degree_level":"Doctoral","degree_discipline":"Mechanical and aerospace engineering (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Nair, Satish S., 1960-"],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-24T03:08:32Z","subjects":[],"languages":["eng","English"],"rights":["OpenAccess."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/4350"],"render_values":[{"text":"https://doi.org/10.32469/10355/4350","href":"https://doi.org/10.32469/10355/4350","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/4350","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Nair, Satish S., 1960-"]},{"key":"dc:creator","label":"Author","values":["Jang, Tai Seung, 1971-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-01-12T17:05:32Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-01-12T17:05:32Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical and aerospace engineering (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["OpenAccess."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/4350"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/4350"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on August 2, 2007)","Vita.","Thesis (Ph. D.) University of Missouri-Columbia 2006."]},{"key":"dc:description.abstract","label":"Abstract","values":["Modeling approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on prefrontal cortical cells are elucidated with two possible hypotheses, and a systematic methodology to study the excitability of cells under inhibitory post synaptic currents (IPSCs) is developed. PART II focuses on mathematical models at the systems level. Specifically, thermal physiology models of the entire human body are developed using statistical and black box (artificial neural network, ANN) techniques.The MU 2-D Man, a human thermal model has been developed for designing an automatic thermal comfort control strategy for NASA astronaut space suits and for the US Air Force warfighters in chemo-bio suits. The model has been enhanced using more accurate modeling of digits incorporating arterio-venous anastomoses (AVA) mechanisms that the fingers and toes use for better control of heat transfer."]},{"key":"dc:title","label":"Title","values":["Specific bio-modeling and analysis techniques at cellular and systems level"]}]}],"canonical_facts":{"dc:contributor.advisor":["Nair, Satish S., 1960-"],"dc:creator":["Jang, Tai Seung, 1971-"],"dc:date.accessioned":["2010-01-12T17:05:32Z"],"dc:date.available":["2010-01-12T17:05:32Z"],"dc:date.issued":["2006"],"dc:description":["The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Title from title screen of research.pdf file (viewed on August 2, 2007)","Vita.","Thesis (Ph. D.) University of Missouri-Columbia 2006."],"dc:description.abstract":["Modeling approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on prefrontal cortical cells are elucidated with two possible hypotheses, and a systematic methodology to study the excitability of cells under inhibitory post synaptic currents (IPSCs) is developed. PART II focuses on mathematical models at the systems level. Specifically, thermal physiology models of the entire human body are developed using statistical and black box (artificial neural network, ANN) techniques.The MU 2-D Man, a human thermal model has been developed for designing an automatic thermal comfort control strategy for NASA astronaut space suits and for the US Air Force warfighters in chemo-bio suits. The model has been enhanced using more accurate modeling of digits incorporating arterio-venous anastomoses (AVA) mechanisms that the fingers and toes use for better control of heat transfer."],"dc:identifier.doi":["https://doi.org/10.32469/10355/4350"],"dc:identifier.uri":["https://hdl.handle.net/10355/4350"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["OpenAccess."],"dc:title":["Specific bio-modeling and analysis techniques at cellular and systems level"],"dc:type":["Thesis"],"thesis:degree_discipline":["Mechanical and aerospace engineering (MU)"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Ph. D."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:08:32Z"}