{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/42989"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/42989","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"EGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's disease","abstract":"Previous work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease pathology, reduces cognitive impairments; however, approximately 1-month of exercise started at 80-days failed to provide cognitive improvements for male mice. Additionally, research has shown that EGCG, a botanical polyphenol, can reduce amyloid-beta levels, mitigate oxidative stress and reduce some of the cognitive impairments associated with Alzheimer's disease in the Tg2576 murine model; however, oral administration of EGCG had not been yet evaluated in the TgCRND8 strain. The present study investigated the effects of 4-months of exercise treatment, implemented at the beginning of pathology development (2-months of age), in conjunction with the effects of EGCG treatment on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the Barnes maze. Four-months of EGCG and exercise treatment reversed nest building and spatial learning deficits, and lowered soluble, Ab1-42 levels in the cortex of Tg animals. This research was supported by NIH grant funding (2P01 AG18357).","abstract_html":"Previous work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease pathology, reduces cognitive impairments; however, approximately 1-month of exercise started at 80-days failed to provide cognitive improvements for male mice. Additionally, research has shown that EGCG, a botanical polyphenol, can reduce amyloid-beta levels, mitigate oxidative stress and reduce some of the cognitive impairments associated with Alzheimer's disease in the Tg2576 murine model; however, oral administration of EGCG had not been yet evaluated in the TgCRND8 strain. The present study investigated the effects of 4-months of exercise treatment, implemented at the beginning of pathology development (2-months of age), in conjunction with the effects of EGCG treatment on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the Barnes maze. Four-months of EGCG and exercise treatment reversed nest building and spatial learning deficits, and lowered soluble, Ab1-42 levels in the cortex of Tg animals. This research was supported by NIH grant funding (2P01 AG18357).","abstract_has_math":false,"creators":["Walker, Jennifer M., 1985-"],"institution":"University of Missouri--Columbia","degree_name":"Ph. D.","degree_level":"Doctoral","degree_discipline":"Psychological sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Schachtman, Todd R."],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-24T03:09:27Z","subjects":["TgCRND8 mouse model"],"languages":["eng","English"],"rights":["OpenAccess."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://doi.org/10.32469/10355/42989"],"render_values":[{"text":"https://doi.org/10.32469/10355/42989","href":"https://doi.org/10.32469/10355/42989","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/42989","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Schachtman, Todd R."]},{"key":"dc:creator","label":"Author","values":["Walker, Jennifer M., 1985-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-05-16T14:58:52Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-05-16T14:58:52Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychological sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["TgCRND8 mouse model"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["OpenAccess."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/42989","https://doi.org/10.32469/10355/42989"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Previous work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease pathology, reduces cognitive impairments; however, approximately 1-month of exercise started at 80-days failed to provide cognitive improvements for male mice. Additionally, research has shown that EGCG, a botanical polyphenol, can reduce amyloid-beta levels, mitigate oxidative stress and reduce some of the cognitive impairments associated with Alzheimer's disease in the Tg2576 murine model; however, oral administration of EGCG had not been yet evaluated in the TgCRND8 strain. The present study investigated the effects of 4-months of exercise treatment, implemented at the beginning of pathology development (2-months of age), in conjunction with the effects of EGCG treatment on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the Barnes maze. Four-months of EGCG and exercise treatment reversed nest building and spatial learning deficits, and lowered soluble, Ab1-42 levels in the cortex of Tg animals. This research was supported by NIH grant funding (2P01 AG18357)."]},{"key":"dc:source","label":"Dc Source","values":["Submitted by the University of Missouri--Columbia Graduate School."]},{"key":"dc:title","label":"Title","values":["EGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Schachtman, Todd R."],"dc:creator":["Walker, Jennifer M., 1985-"],"dc:date.accessioned":["2014-05-16T14:58:52Z"],"dc:date.available":["2014-05-16T14:58:52Z"],"dc:date.issued":["2013"],"dc:description.abstract":["Previous work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease pathology, reduces cognitive impairments; however, approximately 1-month of exercise started at 80-days failed to provide cognitive improvements for male mice. Additionally, research has shown that EGCG, a botanical polyphenol, can reduce amyloid-beta levels, mitigate oxidative stress and reduce some of the cognitive impairments associated with Alzheimer's disease in the Tg2576 murine model; however, oral administration of EGCG had not been yet evaluated in the TgCRND8 strain. The present study investigated the effects of 4-months of exercise treatment, implemented at the beginning of pathology development (2-months of age), in conjunction with the effects of EGCG treatment on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the Barnes maze. Four-months of EGCG and exercise treatment reversed nest building and spatial learning deficits, and lowered soluble, Ab1-42 levels in the cortex of Tg animals. This research was supported by NIH grant funding (2P01 AG18357)."],"dc:identifier.uri":["https://hdl.handle.net/10355/42989","https://doi.org/10.32469/10355/42989"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["OpenAccess."],"dc:source":["Submitted by the University of Missouri--Columbia Graduate School."],"dc:subject":["TgCRND8 mouse model"],"dc:title":["EGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's disease"],"dc:type":["Thesis"],"thesis:degree_discipline":["Psychological sciences (MU)"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Ph. D."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:09:27Z"}