{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/37946"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/37946","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Evaluation of the antimicrobial properties and biocompatibility of polypropylene mesh conjugated with gold nanoparticles","abstract":"Polypropylene (PP) mesh is commonly utilized as a patch for hernia repairs and for pelvic slings. However, biocompatibility and infection rates are a concern. Conjugating gold nanoparticles (AuNPs) to PP mesh may enhance biocompatibility while reducing infection rates. In this study we investigated the size and concentration of gold nanoparticles attached to polypropylene hernia mesh to determine the effects on biocompatibility. The mesh was characterized using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) in order to determine if functional groups and AuNPs had been successfully attached. Differential scanning calorimetry (DSC) was utilized to analyze the heat of fusion and denaturation temperature of the modified PP to determine thermal stability. The antimicrobial properties were assessed using Pseudomonas aeruginosa bacteria. Biocompatibility was evaluated via in vitro cell culture assays using L929 murine fibroblast cells.","abstract_html":"Polypropylene (PP) mesh is commonly utilized as a patch for hernia repairs and for pelvic slings. However, biocompatibility and infection rates are a concern. Conjugating gold nanoparticles (AuNPs) to PP mesh may enhance biocompatibility while reducing infection rates. In this study we investigated the size and concentration of gold nanoparticles attached to polypropylene hernia mesh to determine the effects on biocompatibility. The mesh was characterized using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) in order to determine if functional groups and AuNPs had been successfully attached. Differential scanning calorimetry (DSC) was utilized to analyze the heat of fusion and denaturation temperature of the modified PP to determine thermal stability. The antimicrobial properties were assessed using Pseudomonas aeruginosa bacteria. Biocompatibility was evaluated via in vitro cell culture assays using L929 murine fibroblast cells.","abstract_has_math":false,"creators":["Hartter, Ross"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Biological engineering (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Grant, Sheila Ann"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-24T03:07:57Z","subjects":["gold nanoparticles","biocompatibility","antimicrobial properties","hernia repair"],"languages":["eng","English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10355/37946","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Grant, Sheila Ann"]},{"key":"dc:creator","label":"Author","values":["Hartter, Ross"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-09-09T19:35:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2013-09-09T19:35:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biological engineering (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["gold nanoparticles","biocompatibility","antimicrobial properties","hernia repair"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10355/37946"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Title from PDF of title page (University of Missouri--Columbia, viewed on September 9, 2013).","The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.","Thesis advisor: Dr. Sheila Grant","Includes bibliographical references.","M.S. University of Missouri--Columbia 2013.","Dissertations, Academic -- University of Missouri--Columbia -- Biological engineering.","\"May 2013\""]},{"key":"dc:description.abstract","label":"Abstract","values":["Polypropylene (PP) mesh is commonly utilized as a patch for hernia repairs and for pelvic slings. However, biocompatibility and infection rates are a concern. Conjugating gold nanoparticles (AuNPs) to PP mesh may enhance biocompatibility while reducing infection rates. In this study we investigated the size and concentration of gold nanoparticles attached to polypropylene hernia mesh to determine the effects on biocompatibility. The mesh was characterized using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) in order to determine if functional groups and AuNPs had been successfully attached. Differential scanning calorimetry (DSC) was utilized to analyze the heat of fusion and denaturation temperature of the modified PP to determine thermal stability. The antimicrobial properties were assessed using Pseudomonas aeruginosa bacteria. Biocompatibility was evaluated via in vitro cell culture assays using L929 murine fibroblast cells."]},{"key":"dc:source","label":"Dc Source","values":["Submitted by University of Missouri--Columbia Graduate School."]},{"key":"dc:title","label":"Title","values":["Evaluation of the antimicrobial properties and biocompatibility of polypropylene mesh conjugated with gold nanoparticles"]}]}],"canonical_facts":{"dc:contributor.advisor":["Grant, Sheila Ann"],"dc:creator":["Hartter, Ross"],"dc:date.accessioned":["2013-09-09T19:35:41Z"],"dc:date.available":["2013-09-09T19:35:41Z"],"dc:date.issued":["2013"],"dc:description":["Title from PDF of title page (University of Missouri--Columbia, viewed on September 9, 2013).","The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.","Thesis advisor: Dr. Sheila Grant","Includes bibliographical references.","M.S. University of Missouri--Columbia 2013.","Dissertations, Academic -- University of Missouri--Columbia -- Biological engineering.","\"May 2013\""],"dc:description.abstract":["Polypropylene (PP) mesh is commonly utilized as a patch for hernia repairs and for pelvic slings. However, biocompatibility and infection rates are a concern. Conjugating gold nanoparticles (AuNPs) to PP mesh may enhance biocompatibility while reducing infection rates. In this study we investigated the size and concentration of gold nanoparticles attached to polypropylene hernia mesh to determine the effects on biocompatibility. The mesh was characterized using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) in order to determine if functional groups and AuNPs had been successfully attached. Differential scanning calorimetry (DSC) was utilized to analyze the heat of fusion and denaturation temperature of the modified PP to determine thermal stability. The antimicrobial properties were assessed using Pseudomonas aeruginosa bacteria. Biocompatibility was evaluated via in vitro cell culture assays using L929 murine fibroblast cells."],"dc:identifier.uri":["http://hdl.handle.net/10355/37946"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:source":["Submitted by University of Missouri--Columbia Graduate School."],"dc:subject":["gold nanoparticles","biocompatibility","antimicrobial properties","hernia repair"],"dc:title":["Evaluation of the antimicrobial properties and biocompatibility of polypropylene mesh conjugated with gold nanoparticles"],"dc:type":["Thesis"],"thesis:degree_discipline":["Biological engineering (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:07:57Z"}