{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/35437"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/35437","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia","abstract":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples were procured from the College of Veterinary Medicine, University of Missouri. Subtle evidence of neurodegeneration within each of the brainstem nuclei involved in swallowing was identified in DM samples using hematoxylin & eosin staining. Immunohistochemical methods are currently underway to substantiate this finding. Given that virtually all humans with ALS develop dysphagia, characterization of swallowing impairment is imperative to validate canine DM as a bona fide animal model of ALS. This line of research has the potential to benefit both people and dogs with dysphagia related to ALS and other diseases that cause dysphagia.","abstract_html":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples were procured from the College of Veterinary Medicine, University of Missouri. Subtle evidence of neurodegeneration within each of the brainstem nuclei involved in swallowing was identified in DM samples using hematoxylin & eosin staining. Immunohistochemical methods are currently underway to substantiate this finding. Given that virtually all humans with ALS develop dysphagia, characterization of swallowing impairment is imperative to validate canine DM as a bona fide animal model of ALS. This line of research has the potential to benefit both people and dogs with dysphagia related to ALS and other diseases that cause dysphagia.","abstract_has_math":false,"creators":["Pinnegar, Abbie Jolene"],"institution":"University of Missouri--Columbia","degree_name":"M.H.S.","degree_level":"Masters","degree_discipline":"Communication science and disorders (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Lever, Teresa E."],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-24T03:07:01Z","subjects":["dysphagia","brainstem nuclei","neurodegeneration"],"languages":["eng","English"],"rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10355/35437","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Lever, Teresa E."]},{"key":"dc:creator","label":"Author","values":["Pinnegar, Abbie Jolene"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-05-31T13:18:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2013-05-31T13:18:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Communication science and disorders (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.H.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["dysphagia","brainstem nuclei","neurodegeneration"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Access to files is limited to the campuses of the University of Missouri with SSO login."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10355/35437"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Title from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2013).","The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file","Thesis advisor: Dr. Teresa E. 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Given that virtually all humans with ALS develop dysphagia, characterization of swallowing impairment is imperative to validate canine DM as a bona fide animal model of ALS. This line of research has the potential to benefit both people and dogs with dysphagia related to ALS and other diseases that cause dysphagia."]},{"key":"dc:title","label":"Title","values":["Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia"]}]}],"canonical_facts":{"dc:contributor.advisor":["Lever, Teresa E."],"dc:creator":["Pinnegar, Abbie Jolene"],"dc:date.accessioned":["2013-05-31T13:18:16Z"],"dc:date.available":["2013-05-31T13:18:16Z"],"dc:date.issued":["2012"],"dc:description":["Title from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2013).","The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file","Thesis advisor: Dr. Teresa E. Lever","Includes bibliographical references.","M.H.S. University of Missouri-Columbia 2012.","\"May 2012\""],"dc:description.abstract":["[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples were procured from the College of Veterinary Medicine, University of Missouri. Subtle evidence of neurodegeneration within each of the brainstem nuclei involved in swallowing was identified in DM samples using hematoxylin & eosin staining. Immunohistochemical methods are currently underway to substantiate this finding. Given that virtually all humans with ALS develop dysphagia, characterization of swallowing impairment is imperative to validate canine DM as a bona fide animal model of ALS. 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