{"id":{"repo_id":"mississippi","oai_identifier":"oai:egrove.olemiss.edu:etd-2537"},"canonical_url":"https://search.dev.ndltd.org/etd/mississippi/oai:egrove.olemiss.edu:etd-2537","repository":{"repo_id":"mississippi","name":"University of Mississippi","base_url":"https://egrove.olemiss.edu/do/oai/"},"display":{"title":"Characterization of Drug-Loaded Milled Extrudate Particles Produced by Hot Melt Extrusion Technology for Dry Powder Inhalers","abstract":"The aim of the current investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled formulations. All solid-state characterization studies revealed no change on Theophylline (TH) crystallinity or occurrence of drug-excipient interactions in physical mixtures and formulations. X2 formulation released TH constantly over six hours and has an acceptable particle size range for a DPI, therefore, it was chosen as the best formulation. Due to the pores that created by SB during HME extrusion, X1 released about half of TH after 15 minutes and reached the maximum release on the eighth hour, nevertheless, its particles size was not appropriate for DPI. X3 had the most suitable particle size range for a DPI, however, it had no a sustained-release behavior and its release was the same as a pure TH. For future studies, X2 will be further investigated on Anderson Cascade impaction (ACI), a study that mimic the lung, and <em>in-vivo</em> study will be considered based on the ACI result.","abstract_html":"The aim of the current investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled formulations. All solid-state characterization studies revealed no change on Theophylline (TH) crystallinity or occurrence of drug-excipient interactions in physical mixtures and formulations. X2 formulation released TH constantly over six hours and has an acceptable particle size range for a DPI, therefore, it was chosen as the best formulation. Due to the pores that created by SB during HME extrusion, X1 released about half of TH after 15 minutes and reached the maximum release on the eighth hour, nevertheless, its particles size was not appropriate for DPI. X3 had the most suitable particle size range for a DPI, however, it had no a sustained-release behavior and its release was the same as a pure TH. For future studies, X2 will be further investigated on Anderson Cascade impaction (ACI), a study that mimic the lung, and &lt;em&gt;in-vivo&lt;/em&gt; study will be considered based on the ACI result.","abstract_has_math":false,"creators":["Almotairy, Ahmed"],"institution":null,"degree_name":"M.S. in Pharmaceutical Science","degree_level":"Thesis","degree_discipline":"Pharmaceutics and Drug Delivery","degree_department":null,"school":null,"contributors":["Michael A. Repka","Mahavir Chougule","Samir Ross"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-01-01T08:00:00Z","date_published":"2019-01-01T08:00:00Z","updated_at":"2026-07-24T03:07:00Z","subjects":["Air Jet Milling","Ball Milling","Dry Powder Inhaler","Eudragit RL PO","Hot Melt Extrusion","Theophylline","Pharmacy and Pharmaceutical Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://egrove.olemiss.edu/etd/1538","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Michael A. Repka","Mahavir Chougule","Samir Ross"]},{"key":"dc:creator","label":"Author","values":["Almotairy, Ahmed"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2020-09-22T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pharmaceutics and Drug Delivery"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S. in Pharmaceutical Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Air Jet Milling","Ball Milling","Dry Powder Inhaler","Eudragit RL PO","Hot Melt Extrusion","Theophylline","Pharmacy and Pharmaceutical Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://egrove.olemiss.edu/etd/1538"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The aim of the current investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled formulations. All solid-state characterization studies revealed no change on Theophylline (TH) crystallinity or occurrence of drug-excipient interactions in physical mixtures and formulations. X2 formulation released TH constantly over six hours and has an acceptable particle size range for a DPI, therefore, it was chosen as the best formulation. Due to the pores that created by SB during HME extrusion, X1 released about half of TH after 15 minutes and reached the maximum release on the eighth hour, nevertheless, its particles size was not appropriate for DPI. X3 had the most suitable particle size range for a DPI, however, it had no a sustained-release behavior and its release was the same as a pure TH. For future studies, X2 will be further investigated on Anderson Cascade impaction (ACI), a study that mimic the lung, and <em>in-vivo</em> study will be considered based on the ACI result."]},{"key":"dc:title","label":"Title","values":["Characterization of Drug-Loaded Milled Extrudate Particles Produced by Hot Melt Extrusion Technology for Dry Powder Inhalers"]}]}],"canonical_facts":{"dc:contributor":["Michael A. Repka","Mahavir Chougule","Samir Ross"],"dc:creator":["Almotairy, Ahmed"],"dc:date.available":["2020-09-22T07:00:00Z"],"dc:description.abstract":["The aim of the current investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled formulations. All solid-state characterization studies revealed no change on Theophylline (TH) crystallinity or occurrence of drug-excipient interactions in physical mixtures and formulations. X2 formulation released TH constantly over six hours and has an acceptable particle size range for a DPI, therefore, it was chosen as the best formulation. Due to the pores that created by SB during HME extrusion, X1 released about half of TH after 15 minutes and reached the maximum release on the eighth hour, nevertheless, its particles size was not appropriate for DPI. X3 had the most suitable particle size range for a DPI, however, it had no a sustained-release behavior and its release was the same as a pure TH. For future studies, X2 will be further investigated on Anderson Cascade impaction (ACI), a study that mimic the lung, and <em>in-vivo</em> study will be considered based on the ACI result."],"dc:identifier":["https://egrove.olemiss.edu/etd/1538"],"dc:subject":["Air Jet Milling","Ball Milling","Dry Powder Inhaler","Eudragit RL PO","Hot Melt Extrusion","Theophylline","Pharmacy and Pharmaceutical Sciences"],"dc:title":["Characterization of Drug-Loaded Milled Extrudate Particles Produced by Hot Melt Extrusion Technology for Dry Powder Inhalers"],"thesis:degree_discipline":["Pharmaceutics and Drug Delivery"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S. in Pharmaceutical Science"]},"updated_at":"2026-07-24T03:07:00Z"}