Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the SF-12v2 were established in terms of its construct validity and internal consistency reliability using confirmatory factor analysis (CFA). The measurement invariance of the scale was examined using a multi-group CFA based approach. Finally, structural equation modeling (SEM) was used to test a theory driven model to identify psychosocial predictors of HRQOL in the study sample. Results A total of 218 adults with hemophilia completed the survey. The SF-12v2 was found to be psychometrically valid in the study population. The CFA revealed a two-factor model for the SF-12v2 instrument similar to what has been previously established in the literature. The instrument was found to invariant with respect to age, disease severity, and treatment regimen. Results from the SEM analysis suggested that disability, social support, maladaptive coping, and self-efficacy were key predictors of HRQOL among adults with hemophilia. Conclusions The study results indicated that the SF-12v2 is a psychometrically sound instrument to assess HRQOL of adults with hemophilia. Considering that the assumption of measurement invariance was met, future studies can consider that sub-group comparisons among hemophilia patients in terms of HRQOL reflect true differences between groups and are not artifacts of measurement bias. Clinicians and caregivers of hemophilia patients should consider factors such as improving social support provided, emphasizing on the reduction of maladaptive coping strategies, and increasing patient self-efficacy while making key treatment decisions.
","abstract_html":"<p>Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the SF-12v2 were established in terms of its construct validity and internal consistency reliability using confirmatory factor analysis (CFA). The measurement invariance of the scale was examined using a multi-group CFA based approach. Finally, structural equation modeling (SEM) was used to test a theory driven model to identify psychosocial predictors of HRQOL in the study sample. Results A total of 218 adults with hemophilia completed the survey. The SF-12v2 was found to be psychometrically valid in the study population. The CFA revealed a two-factor model for the SF-12v2 instrument similar to what has been previously established in the literature. The instrument was found to invariant with respect to age, disease severity, and treatment regimen. Results from the SEM analysis suggested that disability, social support, maladaptive coping, and self-efficacy were key predictors of HRQOL among adults with hemophilia. Conclusions The study results indicated that the SF-12v2 is a psychometrically sound instrument to assess HRQOL of adults with hemophilia. Considering that the assumption of measurement invariance was met, future studies can consider that sub-group comparisons among hemophilia patients in terms of HRQOL reflect true differences between groups and are not artifacts of measurement bias. Clinicians and caregivers of hemophilia patients should consider factors such as improving social support provided, emphasizing on the reduction of maladaptive coping strategies, and increasing patient self-efficacy while making key treatment decisions.</p>","abstract_has_math":false,"creators":["Shah, Ruchit Mukesh"],"institution":null,"degree_name":"Ph.D. in Pharmaceutical Sciences","degree_level":"Dissertation","degree_discipline":"Pharmacy Administration","degree_department":null,"school":null,"contributors":["John P. Bentley","Marie Barnard","Amit S. Patel"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-01-01T08:00:00Z","date_published":"2016-01-01T08:00:00Z","updated_at":"2026-07-24T03:05:53Z","subjects":["Hemophilia","Hrqol","Invariance","Psychometrics","Sf-12V2","Pharmacy and Pharmaceutical Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://egrove.olemiss.edu/etd/743","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["John P. Bentley","Marie Barnard","Amit S. Patel"]},{"key":"dc:creator","label":"Author","values":["Shah, Ruchit Mukesh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2019-06-20T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pharmacy Administration"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D. in Pharmaceutical Sciences"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hemophilia","Hrqol","Invariance","Psychometrics","Sf-12V2","Pharmacy and Pharmaceutical Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://egrove.olemiss.edu/etd/743"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the SF-12v2 were established in terms of its construct validity and internal consistency reliability using confirmatory factor analysis (CFA). The measurement invariance of the scale was examined using a multi-group CFA based approach. Finally, structural equation modeling (SEM) was used to test a theory driven model to identify psychosocial predictors of HRQOL in the study sample. Results A total of 218 adults with hemophilia completed the survey. The SF-12v2 was found to be psychometrically valid in the study population. The CFA revealed a two-factor model for the SF-12v2 instrument similar to what has been previously established in the literature. The instrument was found to invariant with respect to age, disease severity, and treatment regimen. Results from the SEM analysis suggested that disability, social support, maladaptive coping, and self-efficacy were key predictors of HRQOL among adults with hemophilia. Conclusions The study results indicated that the SF-12v2 is a psychometrically sound instrument to assess HRQOL of adults with hemophilia. Considering that the assumption of measurement invariance was met, future studies can consider that sub-group comparisons among hemophilia patients in terms of HRQOL reflect true differences between groups and are not artifacts of measurement bias. Clinicians and caregivers of hemophilia patients should consider factors such as improving social support provided, emphasizing on the reduction of maladaptive coping strategies, and increasing patient self-efficacy while making key treatment decisions.
"]},{"key":"dc:title","label":"Title","values":["Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia"]}]}],"canonical_facts":{"dc:contributor":["John P. Bentley","Marie Barnard","Amit S. Patel"],"dc:creator":["Shah, Ruchit Mukesh"],"dc:date.available":["2019-06-20T07:00:00Z"],"dc:description.abstract":["Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the SF-12v2 were established in terms of its construct validity and internal consistency reliability using confirmatory factor analysis (CFA). The measurement invariance of the scale was examined using a multi-group CFA based approach. Finally, structural equation modeling (SEM) was used to test a theory driven model to identify psychosocial predictors of HRQOL in the study sample. Results A total of 218 adults with hemophilia completed the survey. The SF-12v2 was found to be psychometrically valid in the study population. The CFA revealed a two-factor model for the SF-12v2 instrument similar to what has been previously established in the literature. The instrument was found to invariant with respect to age, disease severity, and treatment regimen. Results from the SEM analysis suggested that disability, social support, maladaptive coping, and self-efficacy were key predictors of HRQOL among adults with hemophilia. Conclusions The study results indicated that the SF-12v2 is a psychometrically sound instrument to assess HRQOL of adults with hemophilia. Considering that the assumption of measurement invariance was met, future studies can consider that sub-group comparisons among hemophilia patients in terms of HRQOL reflect true differences between groups and are not artifacts of measurement bias. Clinicians and caregivers of hemophilia patients should consider factors such as improving social support provided, emphasizing on the reduction of maladaptive coping strategies, and increasing patient self-efficacy while making key treatment decisions.
"],"dc:identifier":["https://egrove.olemiss.edu/etd/743"],"dc:subject":["Hemophilia","Hrqol","Invariance","Psychometrics","Sf-12V2","Pharmacy and Pharmaceutical Sciences"],"dc:title":["Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia"],"thesis:degree_discipline":["Pharmacy Administration"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D. in Pharmaceutical Sciences"]},"updated_at":"2026-07-24T03:05:53Z"}