THE USE OF THE CONE-BEAM COMPUTED TOMOGRAPHY FUSION IMAGING AND OF DEDICATED SOFTWARE FOR ABLATION VOLUME PREDICTION IN PERCUTANEOUS MICROWAVE ABLATION OF LIVER PRIMARY TUMORS
type: CreativeWork
description: Purpose To evaluate the clinical impact of a protocol for image-guided percutaneous thermal ablation of primary liver tumors that involves the use of cone-beam computed tomography (CBCT), fusion imaging and of a software for ablation volume prediction. Materials and Methods This study included 80 consecutive patients with 101 hepatocellular carcinomas (HCCs) treated with image-guided percutaneous microwave ablation (MWA) between 01/202106/ 2022 in a single institution: Fondazione IRCCS Cà Granda – Ospedale Maggiore Policlinico, Milan, Italy. Patients were divided in 2 groups: Group A, treated following a specific protocol which involved the use of CBCT, fusion imaging and of a software for ablation volume prediction (41 HCCs in 37 patients), and Group B, treated with standard ultrasound (US) guidance (60 HCCs in 43 patients). Data regarding patients, tumors and procedures were registered. Images from follow-up CT/MR exams performed at 1, 3 and 6 months were reviewed to assess outcomes as residual disease, local tumor progression, intrahepatic distant recurrence, local and overall disease survival rates. Follow-up at 1, 3 and 6 months in group A and B was available in 100%, 57%, 38% and in 100%, 49% and 35% of cases respectively. Ablation response at 1 month was evaluated according to the Modified Response Evaluation Criteria In Solid Tumours (mRECIST) for HCC. A comparison of baseline variables and outcome rates between groups A and B was performed. For outcomes at 1 month, propensity score weighting was then performed performed to control for confounders in age, tumor location, size, and recurrence Results Among all baseline variables, group A and B only differed regarding age, new-vs-residual target tumor rates (higher in group A) and number of subcapsular or perivascular tumors (higher in group B). Among group A patients the protocol led to repositioning the MWA antenna in 49% of cases. There was a significant difference in local tumor response at 1 month betwee…
abstract: Purpose To evaluate the clinical impact of a protocol for image-guided percutaneous thermal ablation of primary liver tumors that involves the use of cone-beam computed tomography (CBCT), fusion imaging and of a software for ablation volume prediction. Materials and Methods This study included 80 consecutive patients with 101 hepatocellular carcinomas (HCCs) treated with image-guided percutaneous microwave ablation (MWA) between 01/202106/ 2022 in a single institution: Fondazione IRCCS Cà Granda – Ospedale Maggiore Policlinico, Milan, Italy. Patients were divided in 2 groups: Group A, treated following a specific protocol which involved the use of CBCT, fusion imaging and of a software for ablation volume prediction (41 HCCs in 37 patients), and Group B, treated with standard ultrasound (US) guidance (60 HCCs in 43 patients). Data regarding patients, tumors and procedures were registered. Images from follow-up CT/MR exams performed at 1, 3 and 6 months were reviewed to assess outcomes as residual disease, local tumor progression, intrahepatic distant recurrence, local and overall disease survival rates. Follow-up at 1, 3 and 6 months in group A and B was available in 100%, 57%, 38% and in 100%, 49% and 35% of cases respectively. Ablation response at 1 month was evaluated according to the Modified Response Evaluation Criteria In Solid Tumours (mRECIST) for HCC. A comparison of baseline variables and outcome rates between groups A and B was performed. For outcomes at 1 month, propensity score weighting was then performed performed to control for confounders in age, tumor location, size, and recurrence Results Among all baseline variables, group A and B only differed regarding age, new-vs-residual target tumor rates (higher in group A) and number of subcapsular or perivascular tumors (higher in group B). Among group A patients the protocol led to repositioning the MWA antenna in 49% of cases. There was a significant difference in local tumor response at 1 month betwee…
author: BIONDETTI, PIERPAOLO
language: eng
keywords: Interventional oncology, Microwave ablation, Cone-beam CT, Fusion imaging, Hepatocellular carcinoma, Settore MED/36 - Diagnostica per Immagini e Radioterapia
date published: 2022-12-14
date modified: 2026-07-27T20:18:58Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2434/947948

PropertyValue
property ID: DOI
value: 10.13130/biondetti-pierpaolo_phd2022-12-14