LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE
type: CreativeWork
description: The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction.
abstract: The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction.
author: C.C. Spinelli
language: ita
keywords: longevità, eNOS, vascolare, Settore MED/04 - Patologia Generale
date published: 2014-02-04
date modified: 2026-07-27T20:19:15Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2434/231162

PropertyValue
property ID: DOI
value: 10.13130/spinelli-chiara-carmela_phd2014-02-04