{"id":{"repo_id":"milano","oai_identifier":"oai:air.unimi.it:2434/231162"},"canonical_url":"https://search.dev.ndltd.org/etd/milano/oai:air.unimi.it:2434/231162","repository":{"repo_id":"milano","name":"Università degli Studi di Milano","base_url":"https://air.unimi.it/oai/request"},"display":{"title":"LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE","abstract":"The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction.","abstract_html":"The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction.","abstract_has_math":false,"creators":["C.C. Spinelli"],"institution":"Università degli Studi di Milano","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["tutore: S. Bosari ; co-tutore: A. Puca ; direttore del dottorato: M. Clerici","BOSARI, SILVANO","CLERICI, MARIO SALVATORE"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-02-04","date_published":"2014-02-04","updated_at":"2026-07-27T20:19:15Z","subjects":["longevità","eNOS","vascolare","Settore MED/04 - Patologia Generale"],"languages":["ita"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.13130/spinelli-chiara-carmela_phd2014-02-04"],"render_values":[{"text":"10.13130/spinelli-chiara-carmela_phd2014-02-04","href":"https://doi.org/10.13130/spinelli-chiara-carmela_phd2014-02-04","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2434/231162","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["tutore: S. Bosari ; co-tutore: A. Puca ; direttore del dottorato: M. Clerici","C.C. Spinelli","BOSARI, SILVANO","CLERICI, MARIO SALVATORE"]},{"key":"dc:creator","label":"Author","values":["C.C. Spinelli"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-02-04"]},{"key":"dc:publisher","label":"Institution","values":["Università degli Studi di Milano"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["longevità","eNOS","vascolare","Settore MED/04 - Patologia Generale"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ita"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2434/231162","10.13130/spinelli-chiara-carmela_phd2014-02-04"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction."]},{"key":"dc:title","label":"Title","values":["LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE"]}]}],"canonical_facts":{"dc:contributor":["tutore: S. Bosari ; co-tutore: A. Puca ; direttore del dottorato: M. Clerici","C.C. Spinelli","BOSARI, SILVANO","CLERICI, MARIO SALVATORE"],"dc:creator":["C.C. Spinelli"],"dc:date":["2014-02-04"],"dc:description":["The delay in aging observed in long-lived individuals (LLIs) runs in families and has become the object of intense investigation. LLIs are thought to be enriched/depleted in single-nucleotide polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) is highly enriched in three independent LLIs populations. It was part of a four-SNPs haplotype that codified for a wild type-WT, a Longevity Associated Variant-LAV and a Rare Variant-RV. We have demonstrated the ability of the Longevity Associated Variant of BPIFB4, LAV-BPIFB4, to induce an improvement in vascular reactivity in opposition to changes in age. Thus, LAV-BPIFB4 may provide a potential tool for innovative therapeutic strategies aimed at fighting age-related dysfunction."],"dc:identifier":["http://hdl.handle.net/2434/231162","10.13130/spinelli-chiara-carmela_phd2014-02-04"],"dc:language":["ita"],"dc:publisher":["Università degli Studi di Milano"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:subject":["longevità","eNOS","vascolare","Settore MED/04 - Patologia Generale"],"dc:title":["LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-27T20:19:15Z"}