CYTO-GENOTOXIC EFFECTS OF SOME PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) ON THE FRESHWATER BIVALVE ZEBRA MUSSEL (DREISSENA POLYMORPHA)
type: CreativeWork
description: Pharmaceutical and personal care products (PPCPs) are an emerging class of environmental pollutants that are extensively and increasingly being used in human and veterinary medicine. Due to their continuous production, consumption and often abuse, many studies have shown worldwide measurable concentrations of about 100 of these drugs in the aquatic environment in the high ng L-1 to low μg L-1 range. Among these, antimicrobial, antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are three of the most used and frequently detected PPCP classes in aquatic environments. Since these chemicals have physico-chemical characteristics similar to those of harmful xenobiotics, they could be potentially dangerous to aquatic non-target organisms, as they are exposed to contaminants over their whole life span. At present, few studies were carried out in order to evaluate the PPCPs potential toxicity on aquatic organisms. The major part of these researches was aimed to acute toxicity evaluation of few drugs on organisms belonging to different trophic levels. Nonetheless, considering the current low environmental levels, these data are not suitable for an accurate risk assessment since chronic effects are much more probable. In order to enlarge this topic, we decided to evaluate the potential cyto-genotoxicity of a common antimicrobial agent (triclosan; TCS), a widespread antibiotic (trimethoprim; TMP) and three largely used NSAIDs (paracetamol; PCM – diclofenac; DCF – ibuprofen; IBU) on the freshwater bivalve zebra mussel (Dreissena polymorpha). This mussel was chosen as biological model because the invertebrates constitute more the 90% of living species, they play an important role in freshwater ecosystems and are particularly susceptible to environmental stressors. Additionally, previous studies have revealed that D. polymorpha is useful and sensible organism capable of highlighting sub-lethal effects when exposed to synthetic chemicals. In detail, a stepwise in vitro-i…
abstract: Pharmaceutical and personal care products (PPCPs) are an emerging class of environmental pollutants that are extensively and increasingly being used in human and veterinary medicine. Due to their continuous production, consumption and often abuse, many studies have shown worldwide measurable concentrations of about 100 of these drugs in the aquatic environment in the high ng L-1 to low μg L-1 range. Among these, antimicrobial, antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are three of the most used and frequently detected PPCP classes in aquatic environments. Since these chemicals have physico-chemical characteristics similar to those of harmful xenobiotics, they could be potentially dangerous to aquatic non-target organisms, as they are exposed to contaminants over their whole life span. At present, few studies were carried out in order to evaluate the PPCPs potential toxicity on aquatic organisms. The major part of these researches was aimed to acute toxicity evaluation of few drugs on organisms belonging to different trophic levels. Nonetheless, considering the current low environmental levels, these data are not suitable for an accurate risk assessment since chronic effects are much more probable. In order to enlarge this topic, we decided to evaluate the potential cyto-genotoxicity of a common antimicrobial agent (triclosan; TCS), a widespread antibiotic (trimethoprim; TMP) and three largely used NSAIDs (paracetamol; PCM – diclofenac; DCF – ibuprofen; IBU) on the freshwater bivalve zebra mussel (Dreissena polymorpha). This mussel was chosen as biological model because the invertebrates constitute more the 90% of living species, they play an important role in freshwater ecosystems and are particularly susceptible to environmental stressors. Additionally, previous studies have revealed that D. polymorpha is useful and sensible organism capable of highlighting sub-lethal effects when exposed to synthetic chemicals. In detail, a stepwise in vitro-i…
author: M. Parolini
language: eng
keywords: Pharmaceutical and Personal Care Products (PPCPs), cyto-genotoxicity, biomarker, Dreissena polymorpha, Settore BIO/07 - Ecologia
date published: 2010-12-02
date modified: 2026-07-27T20:19:17Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2434/150200

PropertyValue
property ID: DOI
value: 10.13130/parolini-marco_phd2010-12-02