ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
type: CreativeWork
description: In this work, a structural taxonomy of these systems is proposed with the aim of clarifying the possible architectures that can arise when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate cellular uptake and/or improve the transfection efficiency of the resulting nanovectors (Chapter 1). The experimental part of this thesis is organized presenting first the technological data of the prepared lipopolyplexes (Chapter 2), PLA-PEG/lipid nanoparticles (Chapter 3) and LNP (Chapter 4) and then their in vitro performances on polarized macrophages isolated from human blood (Chapter 5).
abstract: In this work, a structural taxonomy of these systems is proposed with the aim of clarifying the possible architectures that can arise when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate cellular uptake and/or improve the transfection efficiency of the resulting nanovectors (Chapter 1). The experimental part of this thesis is organized presenting first the technological data of the prepared lipopolyplexes (Chapter 2), PLA-PEG/lipid nanoparticles (Chapter 3) and LNP (Chapter 4) and then their in vitro performances on polarized macrophages isolated from human blood (Chapter 5).
author: POZZA, CAMILLA
language: eng
keywords: macrophage, targeted gene delivery, non-viral vector, nucleic acid delivery, mRNA delivery, Settore CHEM-07/A - Chimica farmaceutica
date published: 2026-04-17
date modified: 2026-07-27T20:19:12Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2434/1250215