TOOLS AND STRATEGIES FOR THE SYNTHESIS OF PHARMACEUTICAL ACTIVE COMPOUNDS
type: CreativeWork
description: This dissertation presents an overview of three years of research aimed at applying novel tools and strategies for the synthesis of potential pharmaceutical active compounds. In this context, I commenced my research at the University of Milano under the supervision of Professor Daniele Passarella. My work centered on two main projects involving the design, synthesis, and characterization of new pharmaceutical compounds with potential therapeutic applications. These projects focus on convenience and cost-effective synthetic strategies, as detailed in Chapters 1 and 2. I also had the opportunity to spend six months abroad at ICIQ (Tarragona, Spain) in the laboratory of Professor Arjan Kleij. During this time, I worked on the enantioselective synthesis of chiral γ-amino alcohols, which is presented in Chapter 3, as well as the utilization of carbon dioxide as a green starting material to create novel drug-containing macromolecules for future drug-delivery applications, outlined in Chapter 4. In the final part of my Ph.D. program, I moved to Indena SpA (Settala, Italy) to complete my industrial internship, which was a part of my Ph.D. funding. The research conducted during this period focused on the extraction and purification of a component of vaccine adjuvant mixtures, discussed in Chapter 5. Chapter 1 explores the safracin family, a class of alkaloids known for their significant antibacterial and antitumor properties, which were first isolated from bacteria such as Pseudomonas species. This chapter begins with a detailed NMR characterization of Safracin B, an important intermediate in the synthesis of commercially available anticancer drugs. We then report on the synthetic conversion of Safracin B into Cyanosafracin B and Safracin A, two additional components of the safracin family, along with their structural elucidation achieved through NMR spectroscopy. The findings presented will enhance the overall understanding of the chemical profile of safracins and provide a…
abstract: This dissertation presents an overview of three years of research aimed at applying novel tools and strategies for the synthesis of potential pharmaceutical active compounds. In this context, I commenced my research at the University of Milano under the supervision of Professor Daniele Passarella. My work centered on two main projects involving the design, synthesis, and characterization of new pharmaceutical compounds with potential therapeutic applications. These projects focus on convenience and cost-effective synthetic strategies, as detailed in Chapters 1 and 2. I also had the opportunity to spend six months abroad at ICIQ (Tarragona, Spain) in the laboratory of Professor Arjan Kleij. During this time, I worked on the enantioselective synthesis of chiral γ-amino alcohols, which is presented in Chapter 3, as well as the utilization of carbon dioxide as a green starting material to create novel drug-containing macromolecules for future drug-delivery applications, outlined in Chapter 4. In the final part of my Ph.D. program, I moved to Indena SpA (Settala, Italy) to complete my industrial internship, which was a part of my Ph.D. funding. The research conducted during this period focused on the extraction and purification of a component of vaccine adjuvant mixtures, discussed in Chapter 5. Chapter 1 explores the safracin family, a class of alkaloids known for their significant antibacterial and antitumor properties, which were first isolated from bacteria such as Pseudomonas species. This chapter begins with a detailed NMR characterization of Safracin B, an important intermediate in the synthesis of commercially available anticancer drugs. We then report on the synthetic conversion of Safracin B into Cyanosafracin B and Safracin A, two additional components of the safracin family, along with their structural elucidation achieved through NMR spectroscopy. The findings presented will enhance the overall understanding of the chemical profile of safracins and provide a…
author: ORLANDO, PAOLO
language: eng
keywords: Settore CHEM-05/A - Chimica organica
date published: 2025-06-05
date modified: 2026-07-27T20:19:03Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

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property ID: Handle
value: https://hdl.handle.net/2434/1168135