DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
type: CreativeWork
description: The convergence of the COVID-19 pandemic and the rapidly expanding aging population represents a critical intersection fraught with multifaceted social and economic implications. On one front, the emergence of the SARS-CoV-2 virus has precipitated a global health crisis of unprecedented proportions, amplifying preexisting economic vulnerabilities and catalyzing a frenetic pursuit of antiviral therapeutics guided by molecular insights. This dual crisis has underscored the imperative for robust intervention strategies to mitigate the spread of the virus and alleviate its profound socio-economic repercussions. Simultaneously, the demographic landscape is undergoing a profound transformation, as evidenced by a United Nations report revealing a marked escalation in the proportion of elderly individuals within global populations, surging to 15% in 2019 and forecasted to double by 2050. This demographic shift carries profound implications for healthcare systems, social welfare structures, and economic sustainability, particularly given the escalating incidence of neurodegenerative diseases prevalent among the elderly demographic cohort. The escalating prevalence of conditions such as Alzheimer's disease and Parkinson's disease accentuates the pressing need for concerted research efforts aimed at elucidating the underlying mechanisms and advancing therapeutic interventions. Against this backdrop of intersecting crises, my doctoral research endeavors over the past three years have been meticulously focused on the realm of organic chemistry. My primary objective has been the design, synthesis, and characterization of bioactive molecules specifically tailored to target key pathological pathways associated with both COVID-19 infection and neurodegenerative disorders. Through a multidisciplinary approach encompassing molecular modeling, synthetic chemistry, and pharmacological evaluation, my research seeks to unravel the intricate molecular interactions underpinning disease path…
abstract: The convergence of the COVID-19 pandemic and the rapidly expanding aging population represents a critical intersection fraught with multifaceted social and economic implications. On one front, the emergence of the SARS-CoV-2 virus has precipitated a global health crisis of unprecedented proportions, amplifying preexisting economic vulnerabilities and catalyzing a frenetic pursuit of antiviral therapeutics guided by molecular insights. This dual crisis has underscored the imperative for robust intervention strategies to mitigate the spread of the virus and alleviate its profound socio-economic repercussions. Simultaneously, the demographic landscape is undergoing a profound transformation, as evidenced by a United Nations report revealing a marked escalation in the proportion of elderly individuals within global populations, surging to 15% in 2019 and forecasted to double by 2050. This demographic shift carries profound implications for healthcare systems, social welfare structures, and economic sustainability, particularly given the escalating incidence of neurodegenerative diseases prevalent among the elderly demographic cohort. The escalating prevalence of conditions such as Alzheimer's disease and Parkinson's disease accentuates the pressing need for concerted research efforts aimed at elucidating the underlying mechanisms and advancing therapeutic interventions. Against this backdrop of intersecting crises, my doctoral research endeavors over the past three years have been meticulously focused on the realm of organic chemistry. My primary objective has been the design, synthesis, and characterization of bioactive molecules specifically tailored to target key pathological pathways associated with both COVID-19 infection and neurodegenerative disorders. Through a multidisciplinary approach encompassing molecular modeling, synthetic chemistry, and pharmacological evaluation, my research seeks to unravel the intricate molecular interactions underpinning disease path…
author: PEDRINI, MARTINA
language: eng
keywords: Settore CHEM-05/A - Chimica organica
date published: 2024-06-27
date modified: 2026-07-27T20:19:12Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2434/1143955