METAL COMPLEXES AND THEIR BIOLOGICAL ACTIVITY IN VIVO
type: CreativeWork
description: Luminescent transition metal complexes (TMCs) represent a class of compounds with remarkable photophysical and electrochemical properties, arising from their unique electronic structures. Complexes containing Pt(II), Ir(III), Ru(II), Cu(I) for example are characterized by the presence of partially filled d-orbitals, exhibit a range of fascinating phenomena including phosphorescence, long-lived excited states, and tuneable emission wavelengths. These features, in conjunction with their chemical versatility and stability, have rendered TMCs indispensable in numerous fields, spanning optoelectronics, sensing, and bioimaging. Within this diverse landscape of TMCs, platinum complexes have garnered particular attention owing to their exceptional luminescence properties and the pivotal role of supramolecular self-assembly in dictating their behaviour. Thanks to the square planar geometry, when the Pt(II) ion is coordinated to conjugated ligands self-assembly can occur leading to the creation of supramolecular structures. These complexes in the assemblies can exhibit strong metal-metal interactions that engender unique photophysical characteristics, including intense phosphorescence and long-lived excited states [8,9]. The self-assembly of these complexes is strongly medium dependent and can further modulates their electrochemical properties and modify their reactivities enabling the creation of stimuli-responsive materials and sophisticated functional systems. In Professor De Cola's research group, the behaviour of self-assembling platinum complexes has been extensively studied. The possibility of using water-soluble, self-assembling platinum complexes makes them ideal candidates for in vivo imaging applications. It is known that one of the major problems of classic luminescent markers is the presence of oxygen in biological systems, as this is a known quencher of long-lived luminescent states. However, self-assembled structures would protect the metal centre, thus prevent…
abstract: Luminescent transition metal complexes (TMCs) represent a class of compounds with remarkable photophysical and electrochemical properties, arising from their unique electronic structures. Complexes containing Pt(II), Ir(III), Ru(II), Cu(I) for example are characterized by the presence of partially filled d-orbitals, exhibit a range of fascinating phenomena including phosphorescence, long-lived excited states, and tuneable emission wavelengths. These features, in conjunction with their chemical versatility and stability, have rendered TMCs indispensable in numerous fields, spanning optoelectronics, sensing, and bioimaging. Within this diverse landscape of TMCs, platinum complexes have garnered particular attention owing to their exceptional luminescence properties and the pivotal role of supramolecular self-assembly in dictating their behaviour. Thanks to the square planar geometry, when the Pt(II) ion is coordinated to conjugated ligands self-assembly can occur leading to the creation of supramolecular structures. These complexes in the assemblies can exhibit strong metal-metal interactions that engender unique photophysical characteristics, including intense phosphorescence and long-lived excited states [8,9]. The self-assembly of these complexes is strongly medium dependent and can further modulates their electrochemical properties and modify their reactivities enabling the creation of stimuli-responsive materials and sophisticated functional systems. In Professor De Cola's research group, the behaviour of self-assembling platinum complexes has been extensively studied. The possibility of using water-soluble, self-assembling platinum complexes makes them ideal candidates for in vivo imaging applications. It is known that one of the major problems of classic luminescent markers is the presence of oxygen in biological systems, as this is a known quencher of long-lived luminescent states. However, self-assembled structures would protect the metal centre, thus prevent…
author: PECORARO, TANIA
language: ita
keywords: Transition Metal complexe, nanomaterial, nanomedicine, Platinum complexe, Self-assambly in vivo, Settore CHEM-03/A - Chimica generale e inorganica, Settore CHEM-07/A - Chimica farmaceutica, Settore CHEM-05/A - Chimica organica
date published: 2025-01-29
date modified: 2026-07-27T20:19:12Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

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property ID: Handle
value: https://hdl.handle.net/2434/1132395