PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
type: CreativeWork
description: Even though pathology of the urogenital tract in domestic animals is a wide field of research several topics are still poorly investigated, tumors in particular. Moving from this observation, my research is organized into two main topics: canine urothelial carcinoma and tumours of the genital system (ovarian and testicular tumours). My research into urothelial carcinoma began with an analysis of the grading systems proposed in veterinary medicine. The relationship between tumour morphology and clinical behaviour is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based on standardized parameters to predict patient prognosis. Dogs with bladder urothelial carcinoma (BUC) were recently proposed as a “large animal” model for the study of human BUCs due to their similar morphology and metastasis locations. BUC grading systems are consolidated in human medicine, while in veterinary medicine, the BUC grading systems that have been proposed for canine tumours are not yet applied in routine diagnostics. These latter systems have been proposed, decade by decade, over the last thirty years, and the reason for their scarce applications is mainly related to a lack of specific cutoff values and studies assessing their prognostic relevance. However, for any prognostic study, reliable grading is necessary. During the beginning of my PhD, I published a review on grading systems for urothelial carcinomas to give an overview of the BUC grading systems available in both human and veterinary pathology and provide an extensive description and a critical evaluation to support veterinary researchers in the choice of possible grading systems to apply in future studies on canine BUCs. After analysing grading systems, I further studied dog urothelial carcinomas by analysing the microenvironment of these tumours, specifically, I studied the expression of an extracellular matrix protein calle…
abstract: Even though pathology of the urogenital tract in domestic animals is a wide field of research several topics are still poorly investigated, tumors in particular. Moving from this observation, my research is organized into two main topics: canine urothelial carcinoma and tumours of the genital system (ovarian and testicular tumours). My research into urothelial carcinoma began with an analysis of the grading systems proposed in veterinary medicine. The relationship between tumour morphology and clinical behaviour is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based on standardized parameters to predict patient prognosis. Dogs with bladder urothelial carcinoma (BUC) were recently proposed as a “large animal” model for the study of human BUCs due to their similar morphology and metastasis locations. BUC grading systems are consolidated in human medicine, while in veterinary medicine, the BUC grading systems that have been proposed for canine tumours are not yet applied in routine diagnostics. These latter systems have been proposed, decade by decade, over the last thirty years, and the reason for their scarce applications is mainly related to a lack of specific cutoff values and studies assessing their prognostic relevance. However, for any prognostic study, reliable grading is necessary. During the beginning of my PhD, I published a review on grading systems for urothelial carcinomas to give an overview of the BUC grading systems available in both human and veterinary pathology and provide an extensive description and a critical evaluation to support veterinary researchers in the choice of possible grading systems to apply in future studies on canine BUCs. After analysing grading systems, I further studied dog urothelial carcinomas by analysing the microenvironment of these tumours, specifically, I studied the expression of an extracellular matrix protein calle…
author: BRAMBILLA, ELEONORA
language: eng
keywords: Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
date published: 2024-07-08
date modified: 2026-07-27T20:19:03Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

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property ID: Handle
value: https://hdl.handle.net/2434/1069611