CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS

This PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: Study I – Mononuclear phagocyte system cells in murine healthy organs and selected pathological conditions. Study II – Sex-dependent modulation of inflammation in a murine caerulein-induced acute pancreatitis model. Study III – Comparison between two methods of digital image analysis (hot-spot fields vs whole-slide) for the assessment of immune cell infiltrations in a murine caerulein-induced acute pancreatitis model. Study IV – Tumor immune system interaction in a murine model of orthotopic pleural mesothelioma.

Grantor dc:publisher

Università degli Studi di Milano

Year dc:date

2024

Author dc:creator

• BERTOLA, LUCA

Contributors dc:contributor

• supervisor: C. Recordati ; cosupervisor: C. Lecchi ; coordinatore: F. Ceciliani
• L. Bertola
• CECILIANI, FABRIZIO

• Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Handle dc:identifier

https://hdl.handle.net/2434/1068913

OAI identifier oai:identifier

oai:air.unimi.it:2434/1068913