PLANT BIOACTIVE COMPOUNDS FOR SUSTAINABLE NUTRITION AND PREVENTION OF METABOLIC DISEASES
type: CreativeWork
description: Chronic metabolic diseases, including diabetes, obesity, and cardiovascular disorders, represent a significant global health challenge. Their prevalence continues to rise, necessitating innovative approaches to prevention and treatment. This work focus on bioactive compounds derived from legumes and pseudocereals that have emerged as promising therapeutic agents for the treatment of metabolic-related chronic diseases. These compounds include polyphenols and peptides, both renowned for their distinctive bioactivity. Central to this thesis is the rigorous evaluation of the bioactive compounds' efficacy in preventing and ameliorating metabolic-related chronic diseases, such as type 2 diabetes, cardiovascular diseases, and obesity. In vitro and ex vivo studies provides insights into the peptides' therapeutic potential. These studies elucidate the compounds' mechanisms of action and their ability to modulate crucial pathways including their role in modulating glucose metabolism, mitigating oxidative stress, and exerting anti-inflammatory effects. Subsequently, the investigation delves into the characterization of protein’s glycosylation. Advanced analytical techniques, including chromatography and light scattering analysis, are harnessed to elucidate the structural and biochemical attributes of glycoproteins that influence not only their bioactivity but also can contribute to their allergenic potential. In fact, crucial in the study of bioactive peptides, potentially usable for the treatment of chronic disorders, is their potential allergenicity. Cross reactivity with known allergens such as soybean or peanut is indeed a potential issue in the development of these products. In this work, we therefore also focused on studying the interaction of proteins and peptides with dendritic cells and their ability to develop allergic reactions with IgE and IgG antibodies. Furthermore, sustainability considerations play a pivotal role throughout this research. The significance of ve…
abstract: Chronic metabolic diseases, including diabetes, obesity, and cardiovascular disorders, represent a significant global health challenge. Their prevalence continues to rise, necessitating innovative approaches to prevention and treatment. This work focus on bioactive compounds derived from legumes and pseudocereals that have emerged as promising therapeutic agents for the treatment of metabolic-related chronic diseases. These compounds include polyphenols and peptides, both renowned for their distinctive bioactivity. Central to this thesis is the rigorous evaluation of the bioactive compounds' efficacy in preventing and ameliorating metabolic-related chronic diseases, such as type 2 diabetes, cardiovascular diseases, and obesity. In vitro and ex vivo studies provides insights into the peptides' therapeutic potential. These studies elucidate the compounds' mechanisms of action and their ability to modulate crucial pathways including their role in modulating glucose metabolism, mitigating oxidative stress, and exerting anti-inflammatory effects. Subsequently, the investigation delves into the characterization of protein’s glycosylation. Advanced analytical techniques, including chromatography and light scattering analysis, are harnessed to elucidate the structural and biochemical attributes of glycoproteins that influence not only their bioactivity but also can contribute to their allergenic potential. In fact, crucial in the study of bioactive peptides, potentially usable for the treatment of chronic disorders, is their potential allergenicity. Cross reactivity with known allergens such as soybean or peanut is indeed a potential issue in the development of these products. In this work, we therefore also focused on studying the interaction of proteins and peptides with dendritic cells and their ability to develop allergic reactions with IgE and IgG antibodies. Furthermore, sustainability considerations play a pivotal role throughout this research. The significance of ve…
author: HEINZL, GIUDITTA CARLOTTA
language: eng
date published: 2024-02-08
date modified: 2026-07-27T20:18:43Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2434/1022348

PropertyValue
property ID: DOI
value: 10.13130/heinzl-giuditta-carlotta_phd2024-02-08