{"id":{"repo_id":"mcmaster","oai_identifier":"oai:macsphere.mcmaster.ca:11375/26178"},"canonical_url":"https://search.dev.ndltd.org/etd/mcmaster/oai:macsphere.mcmaster.ca:11375/26178","repository":{"repo_id":"mcmaster","name":"McMaster University","base_url":"https://macsphere.mcmaster.ca/server/oai/request"},"display":{"title":"Tetralogy of Fallot Surgical Repair and Associated Right Ventricular Remodeling","abstract":"Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect with a global annual incidence of 40,000 cases. Advances in surgery and perioperative care led to improvements in perioperative mortality and, thus, a growing number of survivors. TOF survivors often suffer from complications related to a failing right ventricle. Follow-up studies evaluating TOF repair strategies suggest an association between the type of surgical repair strategy and late right ventricular health. However, surgical practices remain unchanged and led by institution-level biases. The body of evidence addressing outcomes based on TOF surgical repair strategy is weak and controversies persists on the management of these patients. This thesis comprises 6 chapters that form the foundation of a multi-centre research program on outcomes after TOF surgical repair. The program uses various methodologies to generate evidence with a vision to change surgical practices. Chapter 1 is an introduction providing background on TOF and contemporary areas of controversy. Chapter 2 presents the results of a retrospective analysis evaluating the use of early echocardiogram parameters in predicting late cardiac magnetic resonance imaging evaluation of the right ventricle. Chapter 3 presents the results of a retrospective cohort exploring the association between TOF repair strategy and development of right bundle branch block. Chapter 4 presents the results of a multinational survey aiming to explore contemporary biases in TOF surgical repair strategy selection. Chapter 5 presents the background, rationale, design and baseline cohort characteristics of the Tetralogy of Fallot for Life (TOF LIFE) study. The study is a multi-centre inception cohort study with a follow-up period of 2 years. Finally, Chapter 6 discusses the conclusion, limitations, and future implications of this research program.","abstract_html":"Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect with a global annual incidence of 40,000 cases. Advances in surgery and perioperative care led to improvements in perioperative mortality and, thus, a growing number of survivors. TOF survivors often suffer from complications related to a failing right ventricle. Follow-up studies evaluating TOF repair strategies suggest an association between the type of surgical repair strategy and late right ventricular health. However, surgical practices remain unchanged and led by institution-level biases. The body of evidence addressing outcomes based on TOF surgical repair strategy is weak and controversies persists on the management of these patients. This thesis comprises 6 chapters that form the foundation of a multi-centre research program on outcomes after TOF surgical repair. The program uses various methodologies to generate evidence with a vision to change surgical practices. Chapter 1 is an introduction providing background on TOF and contemporary areas of controversy. Chapter 2 presents the results of a retrospective analysis evaluating the use of early echocardiogram parameters in predicting late cardiac magnetic resonance imaging evaluation of the right ventricle. Chapter 3 presents the results of a retrospective cohort exploring the association between TOF repair strategy and development of right bundle branch block. Chapter 4 presents the results of a multinational survey aiming to explore contemporary biases in TOF surgical repair strategy selection. Chapter 5 presents the background, rationale, design and baseline cohort characteristics of the Tetralogy of Fallot for Life (TOF LIFE) study. The study is a multi-centre inception cohort study with a follow-up period of 2 years. Finally, Chapter 6 discusses the conclusion, limitations, and future implications of this research program.","abstract_has_math":false,"creators":["Hussain, Sara"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Health Research Methodology","school":null,"contributors":[],"advisors":["Whitlock, Richard"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021","date_published":"2021","updated_at":"2026-08-21T16:46:30Z","subjects":["tetralogy of fallot","congenital heart disease","outcomes","observational studies"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11375/26178","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://macsphere.mcmaster.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Amacsphere.mcmaster.ca%3A11375%2F26178","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Whitlock, Richard"]},{"key":"dc:contributor.department","label":"Department","values":["Health Research Methodology"]},{"key":"dc:creator","label":"Author","values":["Hussain, Sara"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2021-01-28T21:30:02Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-01-28T21:30:02Z"]},{"key":"dc:date.issued","label":"Date","values":["2021"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["tetralogy of fallot","congenital heart disease","outcomes","observational studies"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11375/26178"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect with a global annual incidence of 40,000 cases. Advances in surgery and perioperative care led to improvements in perioperative mortality and, thus, a growing number of survivors. TOF survivors often suffer from complications related to a failing right ventricle. Follow-up studies evaluating TOF repair strategies suggest an association between the type of surgical repair strategy and late right ventricular health. However, surgical practices remain unchanged and led by institution-level biases. The body of evidence addressing outcomes based on TOF surgical repair strategy is weak and controversies persists on the management of these patients. This thesis comprises 6 chapters that form the foundation of a multi-centre research program on outcomes after TOF surgical repair. The program uses various methodologies to generate evidence with a vision to change surgical practices. Chapter 1 is an introduction providing background on TOF and contemporary areas of controversy. Chapter 2 presents the results of a retrospective analysis evaluating the use of early echocardiogram parameters in predicting late cardiac magnetic resonance imaging evaluation of the right ventricle. Chapter 3 presents the results of a retrospective cohort exploring the association between TOF repair strategy and development of right bundle branch block. Chapter 4 presents the results of a multinational survey aiming to explore contemporary biases in TOF surgical repair strategy selection. Chapter 5 presents the background, rationale, design and baseline cohort characteristics of the Tetralogy of Fallot for Life (TOF LIFE) study. The study is a multi-centre inception cohort study with a follow-up period of 2 years. Finally, Chapter 6 discusses the conclusion, limitations, and future implications of this research program."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Doctor of Science (PhD)"]},{"key":"dc:title","label":"Title","values":["Tetralogy of Fallot Surgical Repair and Associated Right Ventricular Remodeling"]}]}],"canonical_facts":{"dc:contributor.advisor":["Whitlock, Richard"],"dc:contributor.department":["Health Research Methodology"],"dc:creator":["Hussain, Sara"],"dc:date.accessioned":["2021-01-28T21:30:02Z"],"dc:date.available":["2021-01-28T21:30:02Z"],"dc:date.issued":["2021"],"dc:description.abstract":["Tetralogy of Fallot (TOF) is the most common cyanotic congenital cardiac defect with a global annual incidence of 40,000 cases. Advances in surgery and perioperative care led to improvements in perioperative mortality and, thus, a growing number of survivors. TOF survivors often suffer from complications related to a failing right ventricle. Follow-up studies evaluating TOF repair strategies suggest an association between the type of surgical repair strategy and late right ventricular health. However, surgical practices remain unchanged and led by institution-level biases. The body of evidence addressing outcomes based on TOF surgical repair strategy is weak and controversies persists on the management of these patients. This thesis comprises 6 chapters that form the foundation of a multi-centre research program on outcomes after TOF surgical repair. The program uses various methodologies to generate evidence with a vision to change surgical practices. Chapter 1 is an introduction providing background on TOF and contemporary areas of controversy. Chapter 2 presents the results of a retrospective analysis evaluating the use of early echocardiogram parameters in predicting late cardiac magnetic resonance imaging evaluation of the right ventricle. Chapter 3 presents the results of a retrospective cohort exploring the association between TOF repair strategy and development of right bundle branch block. Chapter 4 presents the results of a multinational survey aiming to explore contemporary biases in TOF surgical repair strategy selection. Chapter 5 presents the background, rationale, design and baseline cohort characteristics of the Tetralogy of Fallot for Life (TOF LIFE) study. The study is a multi-centre inception cohort study with a follow-up period of 2 years. Finally, Chapter 6 discusses the conclusion, limitations, and future implications of this research program."],"dc:description.degree":["Doctor of Science (PhD)"],"dc:identifier.uri":["http://hdl.handle.net/11375/26178"],"dc:language.iso":["en"],"dc:subject":["tetralogy of fallot","congenital heart disease","outcomes","observational studies"],"dc:title":["Tetralogy of Fallot Surgical Repair and Associated Right Ventricular Remodeling"],"dc:type":["Thesis"]},"updated_at":"2026-08-21T16:46:30Z"}