{"id":{"repo_id":"mcmaster","oai_identifier":"oai:macsphere.mcmaster.ca:11375/18665"},"canonical_url":"https://search.dev.ndltd.org/etd/mcmaster/oai:macsphere.mcmaster.ca:11375/18665","repository":{"repo_id":"mcmaster","name":"McMaster University","base_url":"https://macsphere.mcmaster.ca/server/oai/request"},"display":{"title":"The Genetic Basis of Obesity","abstract":"The prevalence of obesity has been mainly be attributed to the rise in an obesogenic environment, in which individuals are more prone to high-dense energy foods and live a sedimentary lifestyle. Familial aggregation of obesity however, has led to numerous studies focused on understanding the genetic basis of this complex disorder. To this effect, this thesis summarizes the current knowledge of obesity genetics, including the monogenic, polygenic and epigenetics field. Given the tremendous contribution of animal models, especially mouse models, to our current knowledge of obesity genetics, this thesis summarizes the methodology of genetic studies in mice, and focuses on how the synergy between human and mouse studies has led to not only the discovery of obesity causal genes, but also their biological contribution to obesity. Lastly, this thesis summarizes a candidate gene approach based on the information from mouse models that have led to identification of a novel variant associated with body mass index (BMI), hip circumference and body adiposity index (BAI) in a multi-ethnic cohort.","abstract_html":"The prevalence of obesity has been mainly be attributed to the rise in an obesogenic environment, in which individuals are more prone to high-dense energy foods and live a sedimentary lifestyle. Familial aggregation of obesity however, has led to numerous studies focused on understanding the genetic basis of this complex disorder. To this effect, this thesis summarizes the current knowledge of obesity genetics, including the monogenic, polygenic and epigenetics field. Given the tremendous contribution of animal models, especially mouse models, to our current knowledge of obesity genetics, this thesis summarizes the methodology of genetic studies in mice, and focuses on how the synergy between human and mouse studies has led to not only the discovery of obesity causal genes, but also their biological contribution to obesity. Lastly, this thesis summarizes a candidate gene approach based on the information from mouse models that have led to identification of a novel variant associated with body mass index (BMI), hip circumference and body adiposity index (BAI) in a multi-ethnic cohort.","abstract_has_math":false,"creators":["Yazdi, Fereshteh"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Epidemiology","school":null,"contributors":[],"advisors":["Meyre, David"],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-08-21T16:46:33Z","subjects":["Obesity","Genetics","Epigenetics","pathophysiology"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11375/18665","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://macsphere.mcmaster.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Amacsphere.mcmaster.ca%3A11375%2F18665","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Meyre, David"]},{"key":"dc:contributor.department","label":"Department","values":["Epidemiology"]},{"key":"dc:creator","label":"Author","values":["Yazdi, Fereshteh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-12-17T15:55:51Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-12-17T15:55:51Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Obesity","Genetics","Epigenetics","pathophysiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11375/18665"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This work contains a summary of the current genetic, epigenetic and metagenomic knowledge of obesity, as well as an extensive overview of current genetic approaches in mouse models of obesity. Lastly, this work presents a candidate gene approach based on mouse models, which finds new variants associated with multiple obesity phenotypes in a multi-ethnic cohort."]},{"key":"dc:description.abstract","label":"Abstract","values":["The prevalence of obesity has been mainly be attributed to the rise in an obesogenic environment, in which individuals are more prone to high-dense energy foods and live a sedimentary lifestyle. Familial aggregation of obesity however, has led to numerous studies focused on understanding the genetic basis of this complex disorder. To this effect, this thesis summarizes the current knowledge of obesity genetics, including the monogenic, polygenic and epigenetics field. Given the tremendous contribution of animal models, especially mouse models, to our current knowledge of obesity genetics, this thesis summarizes the methodology of genetic studies in mice, and focuses on how the synergy between human and mouse studies has led to not only the discovery of obesity causal genes, but also their biological contribution to obesity. Lastly, this thesis summarizes a candidate gene approach based on the information from mouse models that have led to identification of a novel variant associated with body mass index (BMI), hip circumference and body adiposity index (BAI) in a multi-ethnic cohort."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science (MSc)"]},{"key":"dc:title","label":"Title","values":["The Genetic Basis of Obesity"]}]}],"canonical_facts":{"dc:contributor.advisor":["Meyre, David"],"dc:contributor.department":["Epidemiology"],"dc:creator":["Yazdi, Fereshteh"],"dc:date.accessioned":["2015-12-17T15:55:51Z"],"dc:date.available":["2015-12-17T15:55:51Z"],"dc:description":["This work contains a summary of the current genetic, epigenetic and metagenomic knowledge of obesity, as well as an extensive overview of current genetic approaches in mouse models of obesity. Lastly, this work presents a candidate gene approach based on mouse models, which finds new variants associated with multiple obesity phenotypes in a multi-ethnic cohort."],"dc:description.abstract":["The prevalence of obesity has been mainly be attributed to the rise in an obesogenic environment, in which individuals are more prone to high-dense energy foods and live a sedimentary lifestyle. Familial aggregation of obesity however, has led to numerous studies focused on understanding the genetic basis of this complex disorder. To this effect, this thesis summarizes the current knowledge of obesity genetics, including the monogenic, polygenic and epigenetics field. Given the tremendous contribution of animal models, especially mouse models, to our current knowledge of obesity genetics, this thesis summarizes the methodology of genetic studies in mice, and focuses on how the synergy between human and mouse studies has led to not only the discovery of obesity causal genes, but also their biological contribution to obesity. Lastly, this thesis summarizes a candidate gene approach based on the information from mouse models that have led to identification of a novel variant associated with body mass index (BMI), hip circumference and body adiposity index (BAI) in a multi-ethnic cohort."],"dc:description.degree":["Master of Science (MSc)"],"dc:identifier.uri":["http://hdl.handle.net/11375/18665"],"dc:language.iso":["en_US"],"dc:subject":["Obesity","Genetics","Epigenetics","pathophysiology"],"dc:title":["The Genetic Basis of Obesity"],"dc:type":["Thesis"]},"updated_at":"2026-08-21T16:46:33Z"}