{"id":{"repo_id":"maryland","oai_identifier":"oai:drum.lib.umd.edu:1903/19767"},"canonical_url":"https://search.dev.ndltd.org/etd/maryland/oai:drum.lib.umd.edu:1903/19767","repository":{"repo_id":"maryland","name":"University of Maryland","base_url":"https://api.drum.lib.umd.edu/server/oai/request"},"display":{"title":"MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN","abstract":"It is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women.","abstract_html":"It is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women.","abstract_has_math":false,"creators":["Stennett, Christina"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Epidemiology and Biostatistics","school":null,"contributors":[],"advisors":["Dyerà!o, Typhanye"],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017","date_published":"2017","updated_at":"2026-07-24T03:02:18Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.13016/M2R20RW98"],"render_values":[{"text":"https://doi.org/10.13016/M2R20RW98","href":"https://doi.org/10.13016/M2R20RW98","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/1903/19767","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Dyerà!o, Typhanye"]},{"key":"dc:contributor.department","label":"Department","values":["Epidemiology and Biostatistics"]},{"key":"dc:creator","label":"Author","values":["Stennett, Christina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-09-13T05:31:59Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-09-13T05:31:59Z"]},{"key":"dc:date.issued","label":"Date","values":["2017"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.13016/M2R20RW98"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1903/19767"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["It is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women."]},{"key":"dc:title","label":"Title","values":["MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN"]}]}],"canonical_facts":{"dc:contributor.advisor":["Dyerà!o, Typhanye"],"dc:contributor.department":["Epidemiology and Biostatistics"],"dc:creator":["Stennett, Christina"],"dc:date.accessioned":["2017-09-13T05:31:59Z"],"dc:date.available":["2017-09-13T05:31:59Z"],"dc:date.issued":["2017"],"dc:description.abstract":["It is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women."],"dc:identifier":["https://doi.org/10.13016/M2R20RW98"],"dc:identifier.uri":["http://hdl.handle.net/1903/19767"],"dc:language.iso":["en"],"dc:title":["MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T03:02:18Z"}