{"id":{"repo_id":"maryland","oai_identifier":"oai:drum.lib.umd.edu:1903/190"},"canonical_url":"https://search.dev.ndltd.org/etd/maryland/oai:drum.lib.umd.edu:1903/190","repository":{"repo_id":"maryland","name":"University of Maryland","base_url":"https://api.drum.lib.umd.edu/server/oai/request"},"display":{"title":"INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING","abstract":"Title of Thesis : INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50-75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training . Plasma FVIII:Ag levels showed an increase of 3.5% (152.5±6.7% to 156.0±6.1%, P=0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r= 0.30) and after training (r=0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training.","abstract_html":"Title of Thesis : INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50-75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training . Plasma FVIII:Ag levels showed an increase of 3.5% (152.5±6.7% to 156.0±6.1%, P=0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r= 0.30) and after training (r=0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training.","abstract_has_math":false,"creators":["Gopinathannair, Rakesh"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Kinesiology","school":null,"contributors":[],"advisors":["Hagberg, James M","Brown, Michael D","Phares, Dana A"],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004-02-17","date_published":"2004-02-17","updated_at":"2026-07-24T03:02:10Z","subjects":[],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1903/190","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hagberg, James M","Brown, Michael D","Phares, Dana A"]},{"key":"dc:contributor.department","label":"Department","values":["Kinesiology"]},{"key":"dc:creator","label":"Author","values":["Gopinathannair, Rakesh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2004-05-31T20:08:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2004-05-31T20:08:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2004-02-17"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1903/190"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Title of Thesis : INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50-75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training . Plasma FVIII:Ag levels showed an increase of 3.5% (152.5±6.7% to 156.0±6.1%, P=0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r= 0.30) and after training (r=0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hagberg, James M","Brown, Michael D","Phares, Dana A"],"dc:contributor.department":["Kinesiology"],"dc:creator":["Gopinathannair, Rakesh"],"dc:date.accessioned":["2004-05-31T20:08:08Z"],"dc:date.available":["2004-05-31T20:08:08Z"],"dc:date.issued":["2004-02-17"],"dc:description.abstract":["Title of Thesis : INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50-75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training . Plasma FVIII:Ag levels showed an increase of 3.5% (152.5±6.7% to 156.0±6.1%, P=0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r= 0.30) and after training (r=0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["http://hdl.handle.net/1903/190"],"dc:language.iso":["en_US"],"dc:title":["INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T03:02:10Z"}