Acute pancreatitis, from local defense to remote organ injury
type: CreativeWork
description: Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). Gallstone migration into the common bile duct and alcohol abuse are the most frequent causes of pancreatitis in adults. Heparan sulfate (HS) is a common component of extracellular matrix which lines the ductal cells in the pancreas. During the process of the disease, active enzymes in the pancreas will cause shedding of HS. We have shown that HS is able to start an inflammatory response in the pancreas. This response was mediated via Toll like receptor-4 and involved both MyD88-dependent and –independent pathways. We propose that HS has a role in the monitoring of pancreatic tissue well-being. Acute lung injury is the most common extra-pancreatic complication in the acute pancreatitis. Macrophages are a heterogeneous population based on their anatomical location and their micro-environment. Our data showed an enriched population of CD68+F4/80- macrophages in the lungs of animals with AP. This population had an increased expression of CD206 (a cell marker of alternatively activated macrophages) and CCR2 (the receptor for CCL2, an important chemoattractant for macrophages). Studying lung macrophages for different phenotypic markers, their polarization, activation and recruitment, in the context of acute lung injury, is a novel area to potentially identify interventions which may improve the outcome of acute lung injury. Macrophages are a source of various remodeling cytokines including TGF-β. TGF-β not only participates in the late phase of acute lung injury, but also might be active early in acute lung injury and potentially could contribute to the development of pulmonary edema. Our data showed an increase in the level of TGF-β1 in the lungs of the acute pan…
abstract: Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). Gallstone migration into the common bile duct and alcohol abuse are the most frequent causes of pancreatitis in adults. Heparan sulfate (HS) is a common component of extracellular matrix which lines the ductal cells in the pancreas. During the process of the disease, active enzymes in the pancreas will cause shedding of HS. We have shown that HS is able to start an inflammatory response in the pancreas. This response was mediated via Toll like receptor-4 and involved both MyD88-dependent and –independent pathways. We propose that HS has a role in the monitoring of pancreatic tissue well-being. Acute lung injury is the most common extra-pancreatic complication in the acute pancreatitis. Macrophages are a heterogeneous population based on their anatomical location and their micro-environment. Our data showed an enriched population of CD68+F4/80- macrophages in the lungs of animals with AP. This population had an increased expression of CD206 (a cell marker of alternatively activated macrophages) and CCR2 (the receptor for CCL2, an important chemoattractant for macrophages). Studying lung macrophages for different phenotypic markers, their polarization, activation and recruitment, in the context of acute lung injury, is a novel area to potentially identify interventions which may improve the outcome of acute lung injury. Macrophages are a source of various remodeling cytokines including TGF-β. TGF-β not only participates in the late phase of acute lung injury, but also might be active early in acute lung injury and potentially could contribute to the development of pulmonary edema. Our data showed an increase in the level of TGF-β1 in the lungs of the acute pan…
author: Akbarshahi, Hamid
language: eng
keywords: Surgery, Acute pancreatitis, heparan sulfate, damage associated molecular patterns, toll-like receptor4, MyD88, IRF-3, acute lung injury, macrophages, transforming growth factor-beta, Smad
date published: 2013
date modified: 2026-07-24T02:59:49Z
provider: University of Lund
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Surgery (Lund)