Triggers of autoimmunity. Studies on gestational events.
type: CreativeWork
description: Objective The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of developing celiac disease (CD), an additional aim was to determine whether markers of possible infections during early pregnancy was associated with development of tissue transglutaminase (tTG) autoantibodies or CD in the offspring. These aims have been summarized in four independent studies. Study population and Methods The Diabetes Prediction in Skåne (DiPiS) is a population based study where blood samples were obtained at the time of delivery between September 2000 and August 2004 from all mothers in this region (Skåne). The blood samples were analyzed for HLA-DQ alleles and islet autoantibodies. The prospective cohort study Celiac Disease Prediction in Skåne (CiPiS) is part of the DiPiS study, which aims to determine the etiology indicators of celiac disease (CD) in newborn children. Children with HLA-risk alleles associated with CD were screened for tissue transglutaminase autoantibodies (tTGA). CD was established by intestinal biopsy in children with confirmed tTGA. Early pregnancy serum samples (gestational week 10-16) were collected from the Southern Sweden Microbiological biobank (SSM-Biobank). This biobank contains more than 120,000 stored plasma samples that have been obtained between 1986 and 2009 from all pregnant mothers at their first visit to the Maternity Care Center. By combining the SSM-Biobank with DiPiS and CiPiS, a total of 24,000 mothers were identified. All mothers included in this thesis (n=1,748) were analyzed for HLA genotype, islet autoantibodies (GADA, IA-2A and IAA in both early pregnancy samples and at delivery), nine different cytokines, one chemokine (early pregnancy samples), IgM class ent…
abstract: Objective The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of developing celiac disease (CD), an additional aim was to determine whether markers of possible infections during early pregnancy was associated with development of tissue transglutaminase (tTG) autoantibodies or CD in the offspring. These aims have been summarized in four independent studies. Study population and Methods The Diabetes Prediction in Skåne (DiPiS) is a population based study where blood samples were obtained at the time of delivery between September 2000 and August 2004 from all mothers in this region (Skåne). The blood samples were analyzed for HLA-DQ alleles and islet autoantibodies. The prospective cohort study Celiac Disease Prediction in Skåne (CiPiS) is part of the DiPiS study, which aims to determine the etiology indicators of celiac disease (CD) in newborn children. Children with HLA-risk alleles associated with CD were screened for tissue transglutaminase autoantibodies (tTGA). CD was established by intestinal biopsy in children with confirmed tTGA. Early pregnancy serum samples (gestational week 10-16) were collected from the Southern Sweden Microbiological biobank (SSM-Biobank). This biobank contains more than 120,000 stored plasma samples that have been obtained between 1986 and 2009 from all pregnant mothers at their first visit to the Maternity Care Center. By combining the SSM-Biobank with DiPiS and CiPiS, a total of 24,000 mothers were identified. All mothers included in this thesis (n=1,748) were analyzed for HLA genotype, islet autoantibodies (GADA, IA-2A and IAA in both early pregnancy samples and at delivery), nine different cytokines, one chemokine (early pregnancy samples), IgM class ent…
author: Lindehammer, Sabina
language: eng
keywords: Endocrinology and Diabetes, Islet autoantibodies, pregnancy, type 1 diabetes, celiac disease
date published: 2011
date modified: 2026-07-24T02:59:49Z
provider: University of Lund
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Unit of Diabetes and Celiac disease, Clinical Sciences, Malmö.