Ultrasound prediction of large fetuses. Epidemiological and clinical investigations
type: CreativeWork
description: The proportions of newborns with a birth weight (BW) >4,000 g and of macrosomic newborns (BW >4,500 g) have increased during the last two decades, parallel with an increasing maternal pre-pregnancy body mass index (BMI) and age at the time for pregnancy. Delivery of a large fetus, especially >4,500 g might cause perinatal complications for both the mother and her child. The aims of this work were to investigate the detection rate of large-for-gestational age (LGA) term newborns by using a routine fetal two-dimensional (2D) ultrasound examination for fetal growth in the third trimester of pregnancy, and to examine whether the detection rate could be further improved by including maternal pre-pregnancy and pregnancy-related variables to the estimated fetal weight (FW) by developing a prediction formula for risk calculation of LGA newborn. Furthermore, to investigate if the accuracy of BW prediction in prolonged pregnancies and in pregnancies with suspected large fetuses could be further improved by using three-dimensional (3D) ultrasound technique with volumetry of fetal structures. Material and methods. A population-based perinatal register, Perinatal Revision South, was used to identify term singleton pregnancies with a routine ultrasound examination in the third trimester of pregnancy from 1995 through 2009. The difference between the BW z-score and the FW z-score at the ultrasound examination in the third trimester, divided by the time elapsed between ultrasound examination and birth was assessed for each fetus. Maternal variables were evaluated for a possible impact on the third trimester fetal growth using multivariate linear and polynomial regression analyses. In order to develop a prediction model for risk calculation of LGA term newborn the dataset (n=48,809) was divided into a development sample and a validation sample. The development sample was used to identify maternal characteristics associated to LGA using multiple logistic regression analyses. The obta…
abstract: The proportions of newborns with a birth weight (BW) >4,000 g and of macrosomic newborns (BW >4,500 g) have increased during the last two decades, parallel with an increasing maternal pre-pregnancy body mass index (BMI) and age at the time for pregnancy. Delivery of a large fetus, especially >4,500 g might cause perinatal complications for both the mother and her child. The aims of this work were to investigate the detection rate of large-for-gestational age (LGA) term newborns by using a routine fetal two-dimensional (2D) ultrasound examination for fetal growth in the third trimester of pregnancy, and to examine whether the detection rate could be further improved by including maternal pre-pregnancy and pregnancy-related variables to the estimated fetal weight (FW) by developing a prediction formula for risk calculation of LGA newborn. Furthermore, to investigate if the accuracy of BW prediction in prolonged pregnancies and in pregnancies with suspected large fetuses could be further improved by using three-dimensional (3D) ultrasound technique with volumetry of fetal structures. Material and methods. A population-based perinatal register, Perinatal Revision South, was used to identify term singleton pregnancies with a routine ultrasound examination in the third trimester of pregnancy from 1995 through 2009. The difference between the BW z-score and the FW z-score at the ultrasound examination in the third trimester, divided by the time elapsed between ultrasound examination and birth was assessed for each fetus. Maternal variables were evaluated for a possible impact on the third trimester fetal growth using multivariate linear and polynomial regression analyses. In order to develop a prediction model for risk calculation of LGA term newborn the dataset (n=48,809) was divided into a development sample and a validation sample. The development sample was used to identify maternal characteristics associated to LGA using multiple logistic regression analyses. The obta…
author: Lindell, Gun
language: eng
keywords: Gynaecology, Obstetrics and Reproductive Medicine, Two-dimensional ultrasound, three-dimensional ultrasound, fetus, intrauterine growth, maternal characteristic, large-for-gestational age, antenatal calculation, Bayesian theorem, fetal weight, estimation, post-term fetus, fetal macrosomia
date published: 2012
date modified: 2026-07-24T02:59:36Z
provider: University of Lund
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Department of Obstetrics and Gynecology, Lund University