{"id":{"repo_id":"lund","oai_identifier":"oai:lup.lub.lu.se:bc300e77-9492-4dca-84fb-a3c25435105b"},"canonical_url":"https://search.dev.ndltd.org/etd/lund/oai:lup.lub.lu.se:bc300e77-9492-4dca-84fb-a3c25435105b","repository":{"repo_id":"lund","name":"University of Lund","base_url":"https://lup.lub.lu.se/oai"},"display":{"title":"Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors","abstract":"Rheumatoid arthritis (RA) is a systemic disease, with an increased risk of co-morbidity from cardiovascular disease (CVD), in particular among those with severe disease. Environmental risk factors are of potential interest for both prevention and treatment of RA. Our aim was to examine changes in the occurrence of CVD over time and, using immunohistochemistry, study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding background population regarding CVD. Patients were followed for 8 years, and fatal and non-fatal cardiovascular first events were identified. To investigate markers of endothelial activation, we used fourteen patients with active RA who started anti-TNF treatment. Muscle biopsies were taken at baseline and 3 months after start of treatment. To identify incident cases of RA for evaluation of predictors of RA, we used two large surveys, the Malmö Preventive Medicine Program and the Malmö Diet Cancer Study. Cardiovascular morbidity and mortality in the two community based RA cohorts was increased compared to the background population. Treatment with adalimumab was associated with decreased expression of endothelial markers previously associated with severe systemic inflammation in RA. Smoking and a low level of formal education were independent risk factors for RA. Moderate alcohol consumption was associated with a reduced risk of RA. Reduced pulmonary function was not associated with future RA, but smoking and low socioeconomic status were independent predictors of RA.","abstract_html":"Rheumatoid arthritis (RA) is a systemic disease, with an increased risk of co-morbidity from cardiovascular disease (CVD), in particular among those with severe disease. Environmental risk factors are of potential interest for both prevention and treatment of RA. Our aim was to examine changes in the occurrence of CVD over time and, using immunohistochemistry, study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding background population regarding CVD. Patients were followed for 8 years, and fatal and non-fatal cardiovascular first events were identified. To investigate markers of endothelial activation, we used fourteen patients with active RA who started anti-TNF treatment. Muscle biopsies were taken at baseline and 3 months after start of treatment. To identify incident cases of RA for evaluation of predictors of RA, we used two large surveys, the Malmö Preventive Medicine Program and the Malmö Diet Cancer Study. Cardiovascular morbidity and mortality in the two community based RA cohorts was increased compared to the background population. Treatment with adalimumab was associated with decreased expression of endothelial markers previously associated with severe systemic inflammation in RA. Smoking and a low level of formal education were independent risk factors for RA. Moderate alcohol consumption was associated with a reduced risk of RA. Reduced pulmonary function was not associated with future RA, but smoking and low socioeconomic status were independent predictors of RA.","abstract_has_math":false,"creators":["Bergström, Ulf"],"institution":"Unit of Rheumatology, Dept of Clinical Sciences, Malmö.","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T02:59:36Z","subjects":["Other Clinical Medicine","Rheumatoid arthritis","Cardiovascular disease and Risk factors"],"languages":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["urn:isbn:978-91-86671-90-7"],"render_values":[{"text":"urn:isbn:978-91-86671-90-7","href":null,"code":true}]}]},"links":{"outbound_url":"https://lup.lub.lu.se/record/1894489","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Bergström, Ulf"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Unit of Rheumatology, Dept of Clinical Sciences, Malmö."]},{"key":"dc:type","label":"Dc Type","values":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Other Clinical Medicine","Rheumatoid arthritis","Cardiovascular disease and Risk factors"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://lup.lub.lu.se/record/1894489","urn:isbn:978-91-86671-90-7","https://portal.research.lu.se/files/3382985/1977698.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Rheumatoid arthritis (RA) is a systemic disease, with an increased risk of co-morbidity from cardiovascular disease (CVD), in particular among those with severe disease. Environmental risk factors are of potential interest for both prevention and treatment of RA. Our aim was to examine changes in the occurrence of CVD over time and, using immunohistochemistry, study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding background population regarding CVD. Patients were followed for 8 years, and fatal and non-fatal cardiovascular first events were identified. To investigate markers of endothelial activation, we used fourteen patients with active RA who started anti-TNF treatment. Muscle biopsies were taken at baseline and 3 months after start of treatment. To identify incident cases of RA for evaluation of predictors of RA, we used two large surveys, the Malmö Preventive Medicine Program and the Malmö Diet Cancer Study. Cardiovascular morbidity and mortality in the two community based RA cohorts was increased compared to the background population. Treatment with adalimumab was associated with decreased expression of endothelial markers previously associated with severe systemic inflammation in RA. Smoking and a low level of formal education were independent risk factors for RA. Moderate alcohol consumption was associated with a reduced risk of RA. Reduced pulmonary function was not associated with future RA, but smoking and low socioeconomic status were independent predictors of RA."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2011:42 (2011)","ISSN: 1652-8220"]},{"key":"dc:title","label":"Title","values":["Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors"]}]}],"canonical_facts":{"dc:creator":["Bergström, Ulf"],"dc:date":["2011"],"dc:description":["Rheumatoid arthritis (RA) is a systemic disease, with an increased risk of co-morbidity from cardiovascular disease (CVD), in particular among those with severe disease. Environmental risk factors are of potential interest for both prevention and treatment of RA. Our aim was to examine changes in the occurrence of CVD over time and, using immunohistochemistry, study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding background population regarding CVD. Patients were followed for 8 years, and fatal and non-fatal cardiovascular first events were identified. To investigate markers of endothelial activation, we used fourteen patients with active RA who started anti-TNF treatment. Muscle biopsies were taken at baseline and 3 months after start of treatment. To identify incident cases of RA for evaluation of predictors of RA, we used two large surveys, the Malmö Preventive Medicine Program and the Malmö Diet Cancer Study. Cardiovascular morbidity and mortality in the two community based RA cohorts was increased compared to the background population. Treatment with adalimumab was associated with decreased expression of endothelial markers previously associated with severe systemic inflammation in RA. Smoking and a low level of formal education were independent risk factors for RA. Moderate alcohol consumption was associated with a reduced risk of RA. Reduced pulmonary function was not associated with future RA, but smoking and low socioeconomic status were independent predictors of RA."],"dc:format":["application/pdf"],"dc:identifier":["https://lup.lub.lu.se/record/1894489","urn:isbn:978-91-86671-90-7","https://portal.research.lu.se/files/3382985/1977698.pdf"],"dc:language":["eng"],"dc:publisher":["Unit of Rheumatology, Dept of Clinical Sciences, Malmö."],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2011:42 (2011)","ISSN: 1652-8220"],"dc:subject":["Other Clinical Medicine","Rheumatoid arthritis","Cardiovascular disease and Risk factors"],"dc:title":["Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors"],"dc:type":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]},"updated_at":"2026-07-24T02:59:36Z"}