Bone turnover markers and prediction of bone loss in elderly women
type: CreativeWork
description: Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of bone turnover (BTMs) have shown some degree of fracture predictability. There is also a correlation between rate of decrease of areal bone mineral density (aBMD) and incident fractures. In this study, the correlation between BTMs and rate of bone loss (change of aBMD and ultrasound variables) over 5 years was investigated in the Malmö OPRA cohort of 75-year old women (n = 506 to 601). In addition, correlation of BTMs and bone metabolism, as assessed by scintigraphy, was tested in postmenopausal women (n = 22). Finally, the effect of precision error on the longitudinal monitoring of change in aBMD was assessed in elderly women (n = 690) and in elderly men (n = 211). There was a strong correlation between all bone turnover markers and the results of scintigraphy (total skeletal uptake of 99mTc-labelled methylene diphosphonate), with no significant difference between bone formation markers and bone resorption markers. BTMs correlated to the 5-year rate of change of aBMD, especially in the legs and the total body, and 5-year change in speed of ultrasound. When serial measurements of BTMs were analysed, the mean value of measurements were correlated more strongly to aBMD change than single measurements, and women with constantly high levels of BTMs had higher rates of bone loss. Precision error of aBMD measurement by dual-energy X-ray absorptiometry has an influence on the detection of individuals with aBMD change exceeding the least significant level. The calculated follow-up interval for detection of a change in aBMD beyond the least significant level in more than half of the elderly individuals ranged from 3–32 years, and was dependent on the equipment used and the skeletal …
abstract: Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of bone turnover (BTMs) have shown some degree of fracture predictability. There is also a correlation between rate of decrease of areal bone mineral density (aBMD) and incident fractures. In this study, the correlation between BTMs and rate of bone loss (change of aBMD and ultrasound variables) over 5 years was investigated in the Malmö OPRA cohort of 75-year old women (n = 506 to 601). In addition, correlation of BTMs and bone metabolism, as assessed by scintigraphy, was tested in postmenopausal women (n = 22). Finally, the effect of precision error on the longitudinal monitoring of change in aBMD was assessed in elderly women (n = 690) and in elderly men (n = 211). There was a strong correlation between all bone turnover markers and the results of scintigraphy (total skeletal uptake of 99mTc-labelled methylene diphosphonate), with no significant difference between bone formation markers and bone resorption markers. BTMs correlated to the 5-year rate of change of aBMD, especially in the legs and the total body, and 5-year change in speed of ultrasound. When serial measurements of BTMs were analysed, the mean value of measurements were correlated more strongly to aBMD change than single measurements, and women with constantly high levels of BTMs had higher rates of bone loss. Precision error of aBMD measurement by dual-energy X-ray absorptiometry has an influence on the detection of individuals with aBMD change exceeding the least significant level. The calculated follow-up interval for detection of a change in aBMD beyond the least significant level in more than half of the elderly individuals ranged from 3–32 years, and was dependent on the equipment used and the skeletal …
author: Lenora, Janaka
language: eng
keywords: Orthopaedics, bone turnover markers, DXA, elderly, osteoporosis, scintigraphy, Bone mineral density, quantitative ultrasound of the calcaneus, bone loss
date published: 2009
date modified: 2026-07-24T02:59:49Z
provider: University of Lund
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Lund University