{"id":{"repo_id":"lund","oai_identifier":"oai:lup.lub.lu.se:79c4e392-baad-4723-b31f-a2c2a777fd43"},"canonical_url":"https://search.dev.ndltd.org/etd/lund/oai:lup.lub.lu.se:79c4e392-baad-4723-b31f-a2c2a777fd43","repository":{"repo_id":"lund","name":"University of Lund","base_url":"https://lup.lub.lu.se/oai"},"display":{"title":"Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide","abstract":"Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. Annual incidences of both type 1 and type 2 diabetes were higher than previously described (27.1/100 000 and 378/100 000). Type 1 incidence was bimodal with peaks in 0-19 and 50-80 years. Patients with latent auto-immune diabetes (LADA) were treated either with insulin or conventionally (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better metabolic control compared to those on conventional treatment. Adult type 1 patients with long duration (n=40)were examined for pancreatic antibodies, residual C-peptide, and other autoantibodies and complications, with focus on complications from the connective tissues. After 20-30 years duration of diabetes, 20% of type 1 patients had detectable pancreatic autoantibodies, 23% had still detectable C-peptide. Complications from the connective tissues were as common as retinopathy and increased with duration.","abstract_html":"Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. Annual incidences of both type 1 and type 2 diabetes were higher than previously described (27.1/100 000 and 378/100 000). Type 1 incidence was bimodal with peaks in 0-19 and 50-80 years. Patients with latent auto-immune diabetes (LADA) were treated either with insulin or conventionally (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better metabolic control compared to those on conventional treatment. Adult type 1 patients with long duration (n=40)were examined for pancreatic antibodies, residual C-peptide, and other autoantibodies and complications, with focus on complications from the connective tissues. After 20-30 years duration of diabetes, 20% of type 1 patients had detectable pancreatic autoantibodies, 23% had still detectable C-peptide. Complications from the connective tissues were as common as retinopathy and increased with duration.","abstract_has_math":false,"creators":["Thunander, Maria"],"institution":"Medicine (Lund)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T02:59:49Z","subjects":["Other Clinical Medicine","Type 1 diabetes","type 2 diabetes","incidence","epidemiology","c-peptide","classification","antibodies","LADA","insulin","definition","autoimmune diseases","rheumatic antibodies","gastric antibodies","complications"],"languages":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["urn:isbn:978-91-86871-02-4"],"render_values":[{"text":"urn:isbn:978-91-86871-02-4","href":null,"code":true}]}]},"links":{"outbound_url":"https://lup.lub.lu.se/record/4123501","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Thunander, Maria"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Medicine (Lund)"]},{"key":"dc:type","label":"Dc Type","values":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Other Clinical Medicine","Type 1 diabetes","type 2 diabetes","incidence","epidemiology","c-peptide","classification","antibodies","LADA","insulin","definition","autoimmune diseases","rheumatic antibodies","gastric antibodies","complications"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://lup.lub.lu.se/record/4123501","urn:isbn:978-91-86871-02-4","https://portal.research.lu.se/files/3897672/4123833.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. Annual incidences of both type 1 and type 2 diabetes were higher than previously described (27.1/100 000 and 378/100 000). Type 1 incidence was bimodal with peaks in 0-19 and 50-80 years. Patients with latent auto-immune diabetes (LADA) were treated either with insulin or conventionally (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better metabolic control compared to those on conventional treatment. Adult type 1 patients with long duration (n=40)were examined for pancreatic antibodies, residual C-peptide, and other autoantibodies and complications, with focus on complications from the connective tissues. After 20-30 years duration of diabetes, 20% of type 1 patients had detectable pancreatic autoantibodies, 23% had still detectable C-peptide. Complications from the connective tissues were as common as retinopathy and increased with duration."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2011:53 (2011)","ISSN: 1652-8220"]},{"key":"dc:title","label":"Title","values":["Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide"]}]}],"canonical_facts":{"dc:creator":["Thunander, Maria"],"dc:date":["2011"],"dc:description":["Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. Annual incidences of both type 1 and type 2 diabetes were higher than previously described (27.1/100 000 and 378/100 000). Type 1 incidence was bimodal with peaks in 0-19 and 50-80 years. Patients with latent auto-immune diabetes (LADA) were treated either with insulin or conventionally (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better metabolic control compared to those on conventional treatment. Adult type 1 patients with long duration (n=40)were examined for pancreatic antibodies, residual C-peptide, and other autoantibodies and complications, with focus on complications from the connective tissues. After 20-30 years duration of diabetes, 20% of type 1 patients had detectable pancreatic autoantibodies, 23% had still detectable C-peptide. Complications from the connective tissues were as common as retinopathy and increased with duration."],"dc:format":["application/pdf"],"dc:identifier":["https://lup.lub.lu.se/record/4123501","urn:isbn:978-91-86871-02-4","https://portal.research.lu.se/files/3897672/4123833.pdf"],"dc:language":["eng"],"dc:publisher":["Medicine (Lund)"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2011:53 (2011)","ISSN: 1652-8220"],"dc:subject":["Other Clinical Medicine","Type 1 diabetes","type 2 diabetes","incidence","epidemiology","c-peptide","classification","antibodies","LADA","insulin","definition","autoimmune diseases","rheumatic antibodies","gastric antibodies","complications"],"dc:title":["Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide"],"dc:type":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]},"updated_at":"2026-07-24T02:59:49Z"}