{"id":{"repo_id":"lund","oai_identifier":"oai:lup.lub.lu.se:5933f7da-3dcf-44ad-932f-5bfd018ad34e"},"canonical_url":"https://search.dev.ndltd.org/etd/lund/oai:lup.lub.lu.se:5933f7da-3dcf-44ad-932f-5bfd018ad34e","repository":{"repo_id":"lund","name":"University of Lund","base_url":"https://lup.lub.lu.se/oai"},"display":{"title":"Myocardial Topical Negative Pressure","abstract":"The aim of this research was to find out if it is possible to increase myocardial microvasular blood flow by applying a topical negative pressure source directly onto the myocardium. Topical negative pressure is a relatively new wound healing technique. When used in wound therapy, topical negative pressure has been shown to increase microvascular blood flow, to stimulate granulation tissue formation, and to stimulate angiogenesis in the underlying tissue, mainly subcutaneous tissue and skeletal muscle. It was concluded that topical negative pressure of -50 mmHg applied over the LAD region induced a significant increase not only in local microvascular blood flow but also in total coronary blood flow in normal and ischemic myocardium. A significant correlation was found between coronary blood flow changes during TNP and laser Doppler signal. It was also concluded that of pressures between -50 mmHg to -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure, and that no zone of hypoperfusion was observed in the epicardium. And finally it was concluded that there where no significant difference between microvascular blood flow during 20 minutes of continuous and intermittent TNP at -50 mmHg. In conclusion, myocardial applied topical negative pressure may in the future, constitute an alternative therapeutic intervention to stimulate blood flow in the failing myocardium in patients with ischemic heart disease.","abstract_html":"The aim of this research was to find out if it is possible to increase myocardial microvasular blood flow by applying a topical negative pressure source directly onto the myocardium. Topical negative pressure is a relatively new wound healing technique. When used in wound therapy, topical negative pressure has been shown to increase microvascular blood flow, to stimulate granulation tissue formation, and to stimulate angiogenesis in the underlying tissue, mainly subcutaneous tissue and skeletal muscle. It was concluded that topical negative pressure of -50 mmHg applied over the LAD region induced a significant increase not only in local microvascular blood flow but also in total coronary blood flow in normal and ischemic myocardium. A significant correlation was found between coronary blood flow changes during TNP and laser Doppler signal. It was also concluded that of pressures between -50 mmHg to -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure, and that no zone of hypoperfusion was observed in the epicardium. And finally it was concluded that there where no significant difference between microvascular blood flow during 20 minutes of continuous and intermittent TNP at -50 mmHg. In conclusion, myocardial applied topical negative pressure may in the future, constitute an alternative therapeutic intervention to stimulate blood flow in the failing myocardium in patients with ischemic heart disease.","abstract_has_math":false,"creators":["Lindstedt Ingemansson, Sandra"],"institution":"Department of Cardiothoracic Surgery, Clinical Sciences, Lund University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-24T02:59:49Z","subjects":["Cardiology and Cardiovascular Disease","Surgery","coronary blood flow","microvascular blood flow","topical negative pressure (TNP)"],"languages":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["urn:isbn:978-91-85897-69-8"],"render_values":[{"text":"urn:isbn:978-91-85897-69-8","href":null,"code":true}]}]},"links":{"outbound_url":"https://lup.lub.lu.se/record/1034430","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Lindstedt Ingemansson, Sandra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["Department of Cardiothoracic Surgery, Clinical Sciences, Lund University"]},{"key":"dc:type","label":"Dc Type","values":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cardiology and Cardiovascular Disease","Surgery","coronary blood flow","microvascular blood flow","topical negative pressure (TNP)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://lup.lub.lu.se/record/1034430","urn:isbn:978-91-85897-69-8","https://portal.research.lu.se/files/3993230/1034432.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The aim of this research was to find out if it is possible to increase myocardial microvasular blood flow by applying a topical negative pressure source directly onto the myocardium. Topical negative pressure is a relatively new wound healing technique. When used in wound therapy, topical negative pressure has been shown to increase microvascular blood flow, to stimulate granulation tissue formation, and to stimulate angiogenesis in the underlying tissue, mainly subcutaneous tissue and skeletal muscle. It was concluded that topical negative pressure of -50 mmHg applied over the LAD region induced a significant increase not only in local microvascular blood flow but also in total coronary blood flow in normal and ischemic myocardium. A significant correlation was found between coronary blood flow changes during TNP and laser Doppler signal. It was also concluded that of pressures between -50 mmHg to -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure, and that no zone of hypoperfusion was observed in the epicardium. And finally it was concluded that there where no significant difference between microvascular blood flow during 20 minutes of continuous and intermittent TNP at -50 mmHg. In conclusion, myocardial applied topical negative pressure may in the future, constitute an alternative therapeutic intervention to stimulate blood flow in the failing myocardium in patients with ischemic heart disease."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2008:16 (2008)","ISSN: 1652-8220"]},{"key":"dc:title","label":"Title","values":["Myocardial Topical Negative Pressure"]}]}],"canonical_facts":{"dc:creator":["Lindstedt Ingemansson, Sandra"],"dc:date":["2008"],"dc:description":["The aim of this research was to find out if it is possible to increase myocardial microvasular blood flow by applying a topical negative pressure source directly onto the myocardium. Topical negative pressure is a relatively new wound healing technique. When used in wound therapy, topical negative pressure has been shown to increase microvascular blood flow, to stimulate granulation tissue formation, and to stimulate angiogenesis in the underlying tissue, mainly subcutaneous tissue and skeletal muscle. It was concluded that topical negative pressure of -50 mmHg applied over the LAD region induced a significant increase not only in local microvascular blood flow but also in total coronary blood flow in normal and ischemic myocardium. A significant correlation was found between coronary blood flow changes during TNP and laser Doppler signal. It was also concluded that of pressures between -50 mmHg to -150 mmHg, a TNP of -50 mmHg seems to be the most effective negative pressure, and that no zone of hypoperfusion was observed in the epicardium. And finally it was concluded that there where no significant difference between microvascular blood flow during 20 minutes of continuous and intermittent TNP at -50 mmHg. In conclusion, myocardial applied topical negative pressure may in the future, constitute an alternative therapeutic intervention to stimulate blood flow in the failing myocardium in patients with ischemic heart disease."],"dc:format":["application/pdf"],"dc:identifier":["https://lup.lub.lu.se/record/1034430","urn:isbn:978-91-85897-69-8","https://portal.research.lu.se/files/3993230/1034432.pdf"],"dc:language":["eng"],"dc:publisher":["Department of Cardiothoracic Surgery, Clinical Sciences, Lund University"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Lund University Faculty of Medicine Doctoral Dissertation Series; 2008:16 (2008)","ISSN: 1652-8220"],"dc:subject":["Cardiology and Cardiovascular Disease","Surgery","coronary blood flow","microvascular blood flow","topical negative pressure (TNP)"],"dc:title":["Myocardial Topical Negative Pressure"],"dc:type":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]},"updated_at":"2026-07-24T02:59:49Z"}