Osteoarthritis. Epidemiologic and genetic aspects.
type: CreativeWork
description: The purpose of this study was to (I) assess the association between body mass index (BMI) and total hip replacement (THR) and total knee replacement (TKR) due to osteoarthritis (OA), (II) assess the association between the mechanical load of work and THR and TKR due to OA, (III) evaluate the natural history of radiographic hip OA with regards to THR and hip fracture, (IV) to determine the prevalence of radiographic OA in patients with hip fracture, and (V) to examine and compare the inheritance patterns of THR for OA and hip fracture. OA was previously regarded as a consequence of the wear and tear the joint is subjected to during one’s lifetime. At the turn of the century the genetics of OA were of high interest. In recent years there has been renewed interest in the effects of mechanical load on the joint. In Paper I it was found that there was a strong association between being overweight (BMI 25.0–29.9 kg/m2) and the risk for TKR for both genders. This was even stronger for obese individuals (BMI 30.0 kg/m2 or above). This association was weaker for THR and this is in agreement with another recently published study that showed that the effect of BMI is less in THR than TKR. There are probably several factors that influence the effect of body weight on the risk for OA. For example malalignment has an additive effect of body weight on the development of knee OA. The effect may to an extent be purely mechanical, i.e. the increased weight putting more strain on the joint, but it has also been shown that cytokines originating from adipose tissue have an effect on cartilage metabolism. In Paper II the association between profession and total joint replacement in the knee and hip was explored. It was found that male farmers have greatly increased odds for total joint replacement, in both hip and knee, compared to other professions. It is not clear why farming has much greater odds for joint replacement due to OA than other physical labour professions. Farming was also …
abstract: The purpose of this study was to (I) assess the association between body mass index (BMI) and total hip replacement (THR) and total knee replacement (TKR) due to osteoarthritis (OA), (II) assess the association between the mechanical load of work and THR and TKR due to OA, (III) evaluate the natural history of radiographic hip OA with regards to THR and hip fracture, (IV) to determine the prevalence of radiographic OA in patients with hip fracture, and (V) to examine and compare the inheritance patterns of THR for OA and hip fracture. OA was previously regarded as a consequence of the wear and tear the joint is subjected to during one’s lifetime. At the turn of the century the genetics of OA were of high interest. In recent years there has been renewed interest in the effects of mechanical load on the joint. In Paper I it was found that there was a strong association between being overweight (BMI 25.0–29.9 kg/m2) and the risk for TKR for both genders. This was even stronger for obese individuals (BMI 30.0 kg/m2 or above). This association was weaker for THR and this is in agreement with another recently published study that showed that the effect of BMI is less in THR than TKR. There are probably several factors that influence the effect of body weight on the risk for OA. For example malalignment has an additive effect of body weight on the development of knee OA. The effect may to an extent be purely mechanical, i.e. the increased weight putting more strain on the joint, but it has also been shown that cytokines originating from adipose tissue have an effect on cartilage metabolism. In Paper II the association between profession and total joint replacement in the knee and hip was explored. It was found that male farmers have greatly increased odds for total joint replacement, in both hip and knee, compared to other professions. It is not clear why farming has much greater odds for joint replacement due to OA than other physical labour professions. Farming was also …
author: Franklin, Jonas
language: eng
keywords: Orthopaedics, body mass index, knee, hip, epidemiology, Osteoarthritis, occupation, hip fracture, inheritance, natural history
date published: 2010
date modified: 2026-07-24T02:59:49Z
provider: University of Lund
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Lund University