{"id":{"repo_id":"lund","oai_identifier":"oai:lup.lub.lu.se:03a185ea-d5e8-4886-b40a-4baadf6162ee"},"canonical_url":"https://search.dev.ndltd.org/etd/lund/oai:lup.lub.lu.se:03a185ea-d5e8-4886-b40a-4baadf6162ee","repository":{"repo_id":"lund","name":"University of Lund","base_url":"https://lup.lub.lu.se/oai"},"display":{"title":"Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease","abstract":"The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD. In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet. In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet. In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety.","abstract_html":"The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD. In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet. In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet. In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety.","abstract_has_math":false,"creators":["Jönsson, Tommy"],"institution":"Division of Family Medicine Department of Clinical Sciences Lund University Sweden","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-24T03:00:02Z","subjects":["Other Clinical Medicine","Cardiovascular system","diabetologi","sekretion","Endokrinologi","Cardiovascular Disease","Paleolithic Diet","Satiety","Endocrinology","diabetology","secreting systems","Kardiovaskulära systemet"],"languages":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["urn:isbn:978-91-85897-23-0"],"render_values":[{"text":"urn:isbn:978-91-85897-23-0","href":null,"code":true}]}]},"links":{"outbound_url":"https://lup.lub.lu.se/record/599209","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Jönsson, Tommy"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2007"]},{"key":"dc:publisher","label":"Institution","values":["Division of Family Medicine Department of Clinical Sciences Lund University Sweden"]},{"key":"dc:type","label":"Dc Type","values":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Other Clinical Medicine","Cardiovascular system","diabetologi","sekretion","Endokrinologi","Cardiovascular Disease","Paleolithic Diet","Satiety","Endocrinology","diabetology","secreting systems","Kardiovaskulära systemet"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://lup.lub.lu.se/record/599209","urn:isbn:978-91-85897-23-0","https://portal.research.lu.se/files/4733049/631273.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD. In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet. In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet. In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["Faculty of Medicine Doctoral Dissertation Series; 2007:145 (2007)","ISSN: 1652-8220"]},{"key":"dc:title","label":"Title","values":["Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease"]}]}],"canonical_facts":{"dc:creator":["Jönsson, Tommy"],"dc:date":["2007"],"dc:description":["The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD. In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet. In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet. In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety."],"dc:format":["application/pdf"],"dc:identifier":["https://lup.lub.lu.se/record/599209","urn:isbn:978-91-85897-23-0","https://portal.research.lu.se/files/4733049/631273.pdf"],"dc:language":["eng"],"dc:publisher":["Division of Family Medicine Department of Clinical Sciences Lund University Sweden"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Faculty of Medicine Doctoral Dissertation Series; 2007:145 (2007)","ISSN: 1652-8220"],"dc:subject":["Other Clinical Medicine","Cardiovascular system","diabetologi","sekretion","Endokrinologi","Cardiovascular Disease","Paleolithic Diet","Satiety","Endocrinology","diabetology","secreting systems","Kardiovaskulära systemet"],"dc:title":["Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease"],"dc:type":["thesis/doccomp","info:eu-repo/semantics/doctoralThesis","text"]},"updated_at":"2026-07-24T03:00:02Z"}