Exploring the binding of amine and sulfonamide ligands in Rhenium(I) Tricarbonyl and Platinum(II) complexes
type: CreativeWork
description: Platinum is the metal present in various classes of inorganic medicinal agents directed at important diseases such as cancer or viral infections. Several new Pt(II) complexes of polyamine ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide nitrogen formed a bond to Pt. The sulfonamido group donates strongly to Pt and places the dansyl group close to a vacant coordination position, allowing it to stack with bound guanine base (G) when G binds. The emission of the fluorophore decreases with decreasing distance to Pt. Metal nuclide radiopharmaceuticals contain a metal core and an inner ligating unit, usually having chelate rings. The development of the advantageous fac-[99mTc(CO)3(H2O)3]+ precursor has opened new directions for radiolabeling. The non-radioactive fac-[Re(CO)3(H2O)3]+ analogue is useful in understanding the chemistry of agents derived from the [99mTc(CO)3(H2O)3]+ species. To achieve a net neutral coordination unit in radiopharmaceuticals with a fac-M(CO)3+ core (M = Tc, Re), facially coordinated monoanionic tridentate ligands (L-) are needed. Several fac-[Re(CO)3L] complexes containing the sulfonamido group as one terminal ligating group were synthesized and characterized by X-ray crystallography and NMR spectroscopy. For most sulfonamido complexes studied here, the two chelate rings have different pucker chirality, as is commonly found for a broad range of metal complexes. The complexes are stable at neutral and basic pH values and thus have potential for providing a neutral label in radiopharmaceuticals. The NMR signal averaging indicates that the rotations about the N-S and S-C bonds of the sulfonamido group are rapid on the NMR time scale. Understanding the chemical features of the prototypical complexes by using the fac-[Re(CO)3L]-analogue approach and the minimal ligand was the goal of this part of this investigation. fac-[Re(CO)3L]+ complexes containing prototypical NNN or NSN tridentate ligan…
abstract: Platinum is the metal present in various classes of inorganic medicinal agents directed at important diseases such as cancer or viral infections. Several new Pt(II) complexes of polyamine ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide nitrogen formed a bond to Pt. The sulfonamido group donates strongly to Pt and places the dansyl group close to a vacant coordination position, allowing it to stack with bound guanine base (G) when G binds. The emission of the fluorophore decreases with decreasing distance to Pt. Metal nuclide radiopharmaceuticals contain a metal core and an inner ligating unit, usually having chelate rings. The development of the advantageous fac-[99mTc(CO)3(H2O)3]+ precursor has opened new directions for radiolabeling. The non-radioactive fac-[Re(CO)3(H2O)3]+ analogue is useful in understanding the chemistry of agents derived from the [99mTc(CO)3(H2O)3]+ species. To achieve a net neutral coordination unit in radiopharmaceuticals with a fac-M(CO)3+ core (M = Tc, Re), facially coordinated monoanionic tridentate ligands (L-) are needed. Several fac-[Re(CO)3L] complexes containing the sulfonamido group as one terminal ligating group were synthesized and characterized by X-ray crystallography and NMR spectroscopy. For most sulfonamido complexes studied here, the two chelate rings have different pucker chirality, as is commonly found for a broad range of metal complexes. The complexes are stable at neutral and basic pH values and thus have potential for providing a neutral label in radiopharmaceuticals. The NMR signal averaging indicates that the rotations about the N-S and S-C bonds of the sulfonamido group are rapid on the NMR time scale. Understanding the chemical features of the prototypical complexes by using the fac-[Re(CO)3L]-analogue approach and the minimal ligand was the goal of this part of this investigation. fac-[Re(CO)3L]+ complexes containing prototypical NNN or NSN tridentate ligan…
author: Christoforou, Anna Maria
keywords: rhenium tricarbonyl, platinum, sulfonamide ligands
date published: 2007-01-01T08:00:00Z
date modified: 2026-07-24T02:59:31Z
provider: Lousiana State University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Chemistry

PropertyValue
property ID: DOI
value: 10.31390/gradschool_dissertations.1436