{"id":{"repo_id":"london-metro","oai_identifier":"oai:repository.londonmet.ac.uk:3393"},"canonical_url":"https://search.dev.ndltd.org/etd/london-metro/oai:repository.londonmet.ac.uk:3393","repository":{"repo_id":"london-metro","name":"London Metropolitan University","base_url":"https://repository.londonmet.ac.uk/cgi/oai2"},"display":{"title":"Serotonin mediated effects on food intake, feeding body weight and subjective variables","abstract":"The motivation for the main body of work presented in this thesis arose from three sources. Initially, the need to develop and test a reliable, portable and unobtrusive method of observing human feeding behaviour in a clinical setting. Secondly, curiosity concerning the serotonergic modulation of feeding. In practice, to examine the effects of the 5-HT reuptake inhibitor and anti-depressant fluoxetine on food intake and choice, body weight and subjective states in both non-depressed normal-weight and obese subjects. The third and final impetus arose from the observation that, in rats, the expression of meal-induced satiety offered a background against which to examine the possible mechanisms underlying the effects of acute and chronic administration of serotonergic agents on consummatory and behavioural functioning.","abstract_html":"The motivation for the main body of work presented in this thesis arose from three sources. Initially, the need to develop and test a reliable, portable and unobtrusive method of observing human feeding behaviour in a clinical setting. Secondly, curiosity concerning the serotonergic modulation of feeding. In practice, to examine the effects of the 5-HT reuptake inhibitor and anti-depressant fluoxetine on food intake and choice, body weight and subjective states in both non-depressed normal-weight and obese subjects. The third and final impetus arose from the observation that, in rats, the expression of meal-induced satiety offered a background against which to examine the possible mechanisms underlying the effects of acute and chronic administration of serotonergic agents on consummatory and behavioural functioning.","abstract_has_math":false,"creators":["McGuirk, Joan Teresa"],"institution":"London Guildhall University","degree_name":"phd","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1992,"date_issued":"1992-07","date_published":"1992-07","updated_at":"2026-07-24T02:54:30Z","subjects":["610 Medicine & health"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.grantnumber","label":"Dc Identifier Grantnumber","values":["N/A"],"render_values":[{"text":"N/A","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["London Metropolitan University"]},{"key":"dc:creator","label":"Author","values":["McGuirk, Joan Teresa"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1992-07"]},{"key":"dc:date.issued","label":"Date","values":["1992-07"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Human Sciences (SHSC)","Department of Geography"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["London Guildhall University"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://repository.londonmet.ac.uk/3393/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["phd"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["610 Medicine & health"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.grantnumber","label":"Dc Identifier Grantnumber","values":["N/A"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repository.londonmet.ac.uk/3393/1/317257.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The motivation for the main body of work presented in this thesis arose from three sources. Initially, the need to develop and test a reliable, portable and unobtrusive method of observing human feeding behaviour in a clinical setting. Secondly, curiosity concerning the serotonergic modulation of feeding. In practice, to examine the effects of the 5-HT reuptake inhibitor and anti-depressant fluoxetine on food intake and choice, body weight and subjective states in both non-depressed normal-weight and obese subjects. 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